
<p><strong>TOPLINE</strong> Pfizer and BioNTech said Thursday that research shows taking a third dose of their vaccine as a booster protects even more against Covid-19, including the Delta variant, and will ask the Food and Drug Administration for emergency authorization for the shot within the next several weeks.</p>



<h3 class="wp-block-heading" id="h-key-facts">KEY FACTS</h3>



<p>A study not yet released by the companies shows that a third dose of the Pfizer-BioNTech vaccine six months after the second dose protected people against the original strain of Covid-19 as well as the Beta variant.</p>



<p>After six months, the companies’ two-dose vaccine loses some of its ability to protect against getting Covid-19 and developing symptoms, although it continues to work well against preventing severe Covid-19, the companies said, referencing data from their studies and from the health ministry in Israel, which has a highly vaccinated population and has recently seen a wave of the Delta variant spread.</p>



<p>After taking the booster shot, antibodies against the original and Beta variants were “five to 10 times higher,” the companies said in a press release.</p>



<p>The companies believe a booster shot would also increase protection against the Delta variant based on&nbsp;<a href="https://www.nature.com/articles/s41586-021-03693-y" target="_blank" rel="noreferrer noopener">a&nbsp;<em>Nature</em>&nbsp;study</a>&nbsp;which they said suggests that the two-dose vaccine is effective against the variant.</p>



<p>Pfizer and BioNTech in August will launch a trial of a vaccine specifically targeting the Delta variant.</p>



<p>The companies said they will send the data to the FDA “in the coming weeks” for its application for emergency authorization and that they will publish the data in a peer-reviewed journal.</p>



<p>They will also send the data to the European Medicines Agency, which regulates drugs in the European Union, and “in discussion with EU and other regions” about emergency authorizations, a spokesperson said.</p>



<p>A separate study published Thursday in&nbsp;<em>JAMA Oncology</em>&nbsp;found the vaccine was found to be&nbsp;<a href="https://jamanetwork.com/journals/jamaoncology/fullarticle/2781608?guestAccessKey=a006b52c-6abf-414d-b0b9-b57946450d20&amp;utm_source=For_The_Media&amp;utm_medium=referral&amp;utm_campaign=ftm_links&amp;utm_content=tfl&amp;utm_term=070821" target="_blank" rel="noreferrer noopener">safe for cancer patients</a>, although most didn’t develop antibodies until after their second dose, and 14% didn’t develop the antibodies at all.&nbsp;</p>



<h3 class="wp-block-heading" id="h-tangent">TANGENT</h3>



<p>The FDA, which is&nbsp;<a href="https://www.fda.gov/vaccines-blood-biologics/development-approval-process-cber" target="_blank" rel="noreferrer noopener">in charge</a>&nbsp;of approving vaccines,&nbsp;<a href="https://pbs.twimg.com/media/E50SoxnXEAMvs9c.png" target="_blank" rel="noreferrer noopener">released a statement</a>&nbsp;with the CDC Thursday night that appeared to respond to Pfizer and BioNTech’s news. “Americans who have been fully vaccinated do not need a booster shot at this time,” it said. Both agencies and the National Institutes of Health, the statement continued, are researching “whether or when a booster might be necessary.”&nbsp;</p>



<h3 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h3>



<p>Whether booster shots work, and how well, is important because scientists expect that vaccines will&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/06/15/when-will-you-need-a-covid-booster-shot-pfizer-monitors-breakthrough-infections-as-experts-say-more-data-is-needed/?sh=1068ed587f69">lose strength over time</a>. Because the pace of vaccination is so unequal—globally, just&nbsp;<a href="https://ourworldindata.org/grapher/share-people-vaccinated-covid?time=2020-12-02..2021-07-07&amp;country=~OWID_WRL" target="_blank" rel="noreferrer noopener">one in four people</a>&nbsp;have received at least one vaccine dose; in the U.S.,&nbsp;<a href="https://www.forbes.com/sites/jemimamcevoy/2021/07/08/at-least-15-states-wont-reach-70-vaccination-goal-until-2022-or-even-later-at-current-pace/?sh=46a2691532b8">at least 15 states</a>&nbsp;are not on pace to partially or fully vaccinate 70% of residents until 2022—some people are likely to need booster shots before others get their first dose.</p>



<h3 class="wp-block-heading" id="h-further-reading">FURTHER READING</h3>



<p><a href="https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-provide-update-booster-program-light-delta" target="_blank" rel="noreferrer noopener">Pfizer and BioNTech Provide Update on Booster Program in Light of the Delta-Variant</a>&nbsp;<em>(BioNTech)</em></p>



<p><a href="https://www.forbes.com/sites/roberthart/2021/05/18/96-of-people-develop-covid-antibodies-after-just-one-shot-of-pfizer-or-astrazeneca-vaccine-uk-study-finds/?sh=30b7f66699b9">96% Of People Develop Covid Antibodies After Just One Shot Of Pfizer Or AstraZeneca Vaccine, UK Study Finds</a>&nbsp;<em>(Forbes)</em>&nbsp;</p>



<p><a href="https://www.forbes.com/sites/roberthart/2021/06/15/when-will-you-need-a-covid-booster-shot-pfizer-monitors-breakthrough-infections-as-experts-say-more-data-is-needed/?sh=1068ed587f69">When Will You Need A Covid Booster Shot? Pfizer Monitors Breakthrough Infections As Experts Say More Data Is Needed</a>&nbsp;<em>(Forbes)</em></p>



<p><a href="https://ourworldindata.org/grapher/share-people-vaccinated-covid?time=2020-12-02..2021-07-07&amp;country=~OWID_WRL" target="_blank" rel="noreferrer noopener">Share of people who received at least one dose of COVID-19 vaccine</a> <em>(Our World In Data)</em></p>



<p><strong><em>By Graison Dangor, Forbes Staff</em></strong></p>


TOPSHOT-US-HEALTH-VIRUS-STOCKS

Pfizer Will Ask FDA To Authorize Third Covid-19 Shot As A Booster


<p><strong>TOPLINE</strong>: Pfizer’s Covid-19 vaccine is significantly less effective at preventing infection with the Delta variant than previous strains of coronavirus, data from Israel’s health ministry suggests, the latest setback as countries around the world fight to contain the hyper-contagious form of Covid-19 driving outbreaks among children and young people. </p>



<h3 class="wp-block-heading" id="h-key-facts">KEY FACTS</h3>



<p>A full course of the Pfizer-BioNTech vaccine is 64% effective at preventing symptomatic Covid-19, according to an&nbsp;<a href="https://www.ynet.co.il/news/article/rJQ1O5kp00#autoplay" target="_blank" rel="noreferrer noopener">early study&nbsp;</a>by Israel’s health ministry&nbsp;<a href="https://www.bloomberg.com/news/articles/2021-07-05/israel-sees-decline-in-pfizer-vaccine-efficacy-rate-ynet-says" target="_blank" rel="noreferrer noopener">reported</a>&nbsp;Monday, much&nbsp;<a href="https://www.ft.com/content/e7147144-11ff-45bc-96f1-236380c9df5d" target="_blank" rel="noreferrer noopener">lower</a>&nbsp;than&nbsp;<a href="https://www.reuters.com/business/healthcare-pharmaceuticals/pfizer-says-covid-vaccine-highly-effective-against-delta-variant-2021-06-24/" target="_blank" rel="noreferrer noopener">previous</a>&nbsp;estimates of nearly 90%.&nbsp;</p>



<p>The vaccine still appears to be highly effective, 93%, at preventing serious illness and hospitalization, the data shows, though this is also slightly lower than earlier studies suggested and for other variants.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p>



<p>Biotech firm Moderna, which is based on the same type of technology as Pfizer’s jab,&nbsp;<a href="https://investors.modernatx.com/news-releases/news-release-details/moderna-provides-clinical-update-neutralizing-activity-its-covid" target="_blank" rel="noreferrer noopener">said</a>&nbsp;its vaccine remains effective against the Delta variant and that blood samples from fully vaccinated individuals&nbsp;<a href="https://www.npr.org/sections/coronavirus-live-updates/2021/06/30/1011684609/moderna-says-studies-show-its-vaccine-is-effective-against-the-delta-variant" target="_blank" rel="noreferrer noopener">show</a>&nbsp;only a “modest reduction” in antibodies.</p>



<p>Early studies&nbsp;<a href="https://www.npr.org/sections/coronavirus-live-updates/2021/07/01/1012372893/johnson-johnsons-covid-vaccine-is-effective-against-the-delta-variant-studies-fi" target="_blank" rel="noreferrer noopener">indicate</a>&nbsp;the Johnson &amp; Johnson vaccine, the third authorized for use in the U.S., is also effective against the variant, the company said, generating immunity lasting for at least eight months.&nbsp;</p>



<p>Studies from the U.K., where Delta accounts for practically all new cases of Covid-19,&nbsp;<a href="https://www.bloomberg.com/news/articles/2021-06-14/delta-variant-doubles-risk-of-covid-hospitalization-in-study" target="_blank" rel="noreferrer noopener">found</a>&nbsp;the AstraZeneca vaccine to be about 60% effective at preventing symptomatic disease and around 90% effective at preventing hospitalization, a modest drop compared to the Alpha variant that previously dominated.</p>



<p>In vaccines requiring two shots—which covers all mentioned here bar the one-shot Johnson &amp; Johnson—research consistently indicates a much lower level of protection from just one shot,&nbsp;<a href="https://www.forbes.com/sites/alisondurkee/2021/06/30/cdc-wont-change-mask-guidelines-as-delta-variant-spreads-director-says/?sh=bad30f25e75f">underscoring</a>&nbsp;<a href="https://www.axios.com/fauci-vaccination-covid-rates-two-americas-5547f8cd-743a-4789-96bc-10782f967b2c.html" target="_blank" rel="noreferrer noopener">entreaties</a>&nbsp;from public health officials for Americans to get vaccinated.&nbsp;</p>



<h3 class="wp-block-heading" id="h-contra">CONTRA</h3>



<p>The data and research covering how effective vaccines are against Delta are new and, in some instances, incomplete, something that reflects the speed at which Delta has spread. For example, Israel’s health ministry has not revealed the data or the methodology it used to obtain its results and the studies from both Moderna and Johnson &amp; Johnson only looked at how blood samples from a very small number of people behaved in a laboratory setting. Until more data is gathered in a transparent and verifiable way, the figures and results should not be seen as conclusive. The U.K. is likely to prove an invaluable source of information for other countries dealing with the variant as it is facing a new&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/06/14/delta-variant-fueling-uk-covid-surge-could-become-dominant-us-strain-here-are-the-places-most-at-risk/?sh=66a089d04e31">wave</a>&nbsp;of cases&nbsp;<a href="https://news.sky.com/story/covid-19-delta-variant-cases-up-46-in-a-week-as-expert-warns-mutant-strain-will-hit-uk-soon-12347040" target="_blank" rel="noreferrer noopener">driven</a>&nbsp;almost entirely by Delta, especially as it&nbsp;<a href="https://www.bbc.co.uk/news/uk-57725523" target="_blank" rel="noreferrer noopener">prepares</a>&nbsp;to lift all pandemic restrictions.&nbsp;</p>



<h3 class="wp-block-heading" id="h-big-number">BIG NUMBER</h3>



<p>47%. That’s how much of the U.S. population has been fully vaccinated against Covid-19,&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations" target="_blank" rel="noreferrer noopener">according</a>&nbsp;to the CDC. Around 83 million have received a full course of the Pfizer-BioNTech vaccine, 61 million the Moderna vaccine and 12 million the one-shot Johnson &amp; Johnson vaccine. 72,000 people have been fully vaccinated with a two-dose vaccine, though records do not show which.</p>



<h3 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h3>



<p>Health experts, including at the CDC, believe it is&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/06/18/cdc-head-says-dangerous-delta-variant-likely-to-be-dominant-covid-strain-heres-where-its-spreading-fastest/?sh=68f212c86ff5">likely</a>&nbsp;the Delta variant will become the dominant strain in the U.S. It already accounts for around one in four cases of Covid-19,&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions" target="_blank" rel="noreferrer noopener">according</a>&nbsp;to the CDC, and is already the dominant form of the virus in two regions the agency measures (making up around 50-60% of cases in an area covering Iowa, Kansas, Missouri, Nebraska, Colorado, Montana, North Dakota, South Dakota, Utah and Wyoming). Though the WHO recommends all people to keep wearing masks&nbsp;<a href="https://www.forbes.com/sites/alisondurkee/2021/06/25/who-urges-fully-vaccinated-people-to-continue-wearing-masks-as-delta-variant-spreads-but-no-word-from-cdc/?sh=79f3bb9241f9">regardless</a>&nbsp;of their vaccination status, the CDC has not&nbsp;<a href="https://www.forbes.com/sites/alisondurkee/2021/06/30/cdc-wont-change-mask-guidelines-as-delta-variant-spreads-director-says/?sh=863b6855e75f">changed</a>&nbsp;its guidance, recommending people get vaccinated to protect themselves and for local officials to institute their own measures if needed. Few areas have shown signs of doing this and the country&#8217;s&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/07/02/the-least-vaccinated-states-also-earn-the-least-an-analysis-of-data-shows/?sh=6ef093331f5b">low</a>&nbsp;and&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/06/30/here-are-the-groups-that-still-wont-get-the-covid-vaccine-and-why/?sh=3550d46d2ad4">uneven</a>&nbsp;vaccination&nbsp;<a href="https://www.forbes.com/sites/jemimamcevoy/2021/07/04/32-states-didnt-hit-bidens-july-4-vaccine-goal-these-were-the-furthest-from-it/?sh=41ce764132cd">rates</a>&nbsp;across the U.S. has prompted&nbsp;<a href="https://www.axios.com/fauci-vaccination-covid-rates-two-americas-5547f8cd-743a-4789-96bc-10782f967b2c.html" target="_blank" rel="noreferrer noopener">fears</a>&nbsp;the variant will drive new waves of cases in poorly vaccinated areas, especially as practically all pandemic restrictions have been&nbsp;<a href="https://www.forbes.com/sites/jemimamcevoy/2021/07/01/just-one-state-is-left-to-fully-reopen-heres-what-it-is-waiting-for/?sh=777f13d45f33">dropped</a>.</p>



<h3 class="wp-block-heading" id="h-what-to-watch-for">WHAT TO WATCH FOR</h3>



<p>Most pharmaceutical companies—including&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/05/19/astrazenecas-covid-shot-reportedly-works-well-as-a-booster-raising-hopes-in-battle-against-virus-variants/?sh=409a27ea5870">AstraZeneca</a>,&nbsp;<a href="https://www.forbes.com/sites/melissaholzberg/2021/05/04/pfizer-will-file-for-full-fda-approval-for-covid-19-vaccine-by-end-of-may/?sh=21bf069124c0">Pfizer</a>&nbsp;and&nbsp;<a href="https://www.forbes.com/sites/leahrosenbaum/2021/04/29/moderna-invests-to-make-3-billion-covid-vaccines-by-2022/?sh=5d3bade0ac6a">Moderna</a>—are already working on Covid-19 booster shots, which could top up fading immunity over time and give added protection against new variants of the virus. It’s not yet clear&nbsp;<a href="https://www.forbes.com/sites/roberthart/2021/06/15/when-will-you-need-a-covid-booster-shot-pfizer-monitors-breakthrough-infections-as-experts-say-more-data-is-needed/?sh=5a11d8ae7f69">when a booster&nbsp;</a>might be needed. There are also a number of trials&nbsp;<a href="https://www.theguardian.com/society/2021/jun/06/mix-and-match-covid-booster-jabs-may-be-offered-in-uk-vaccine-autumn" target="_blank" rel="noreferrer noopener">exploring</a>&nbsp;what&nbsp;<a href="https://www.washingtonpost.com/health/2021/07/04/johnson-johnson-vaccine-second-dose/" target="_blank" rel="noreferrer noopener">vaccine</a>&nbsp;should be used as a booster and whether it would be more effective to “mix and match” different kinds.&nbsp;</p>



<h3 class="wp-block-heading" id="h-further-reading">FURTHER READING</h3>



<p><a href="https://www.forbes.com/sites/roberthart/2021/07/02/kids-among-most-vulnerable-to-infectious-delta-variant---heres-why-you-should-be-more-worried/?sh=ba4417927011">Kids Among Most Vulnerable To Infectious Delta Variant — Here’s Why You Should Be More Worried</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/roberthart/2021/06/18/cdc-head-says-dangerous-delta-variant-likely-to-be-dominant-covid-strain-heres-where-its-spreading-fastest/?sh=32c085616ff5">CDC Head Says Dangerous Delta Variant Likely To Be Dominant Covid Strain. Here’s Where It’s Spreading Fastest.</a>&nbsp;(Forbes)</p>



<p><a href="https://www.theatlantic.com/health/archive/2021/07/3-principles-now-define-pandemic/619336/" target="_blank" rel="noreferrer noopener">The 3 Simple Rules That Underscore the Danger of Delta</a>&nbsp;(The Atlantic)</p>



<p><a href="https://www.forbes.com/sites/alisondurkee/2021/06/11/here-are-the-biggest-groups-that-are-still-refusing-the-covid-19-vaccine-poll-finds/?sh=5c30db3c42cc">Here Are The Biggest Groups That Are Still Refusing The Covid-19 Vaccine, Poll Finds</a> (Forbes)</p>



<p><strong><em>By Robert Hart, Forbes Staff</em></strong></p>


Tag: fourth wave

FORBES AFRICA SOCIAL MEDIA

Pfizer Will Ask FDA To Authorize Third Covid-19 Shot As A Booster

Pfizer Shot Much Less Effective Against Delta, Israel Study Shows — Here’s What You Need To Know About Variants And Vaccines