
<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>Food recalls in 2023 reached the highest levels the U.S. has recorded since the beginning of the COVID-19 pandemic, mainly driven by undisclosed allergens and listeria contamination, according to a new report released Thursday.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>Some 313 food recalls (impacting products that were still on sale) and alerts (involving products no longer on sale, but may be in consumers’ homes) were announced last year by the Food and Drug Administration and the U.S. Department of Agriculture, an 8% increase from 2022 and the highest number since the COVID pandemic began in 2020, according to a report released Thursday by the nonprofit U.S. Public Research Interest Group Education Fund.</p>



<p>Contaminated food resulted in six deaths and over 1,100 illnesses last year, though the researchers suspect there were more illnesses since most people recover from food poisoning without medical attention.</p>



<p>The most commonly recalled food items in 2023 were snacks like cookies and granola bars, which accounted for one in five recalls, though other commonly recalled foods included fruit—mainly cantaloupes—beef, soup, salads and greens, poultry, cheese, vegetables, supplements and pet food, according to the report.</p>



<p>Almost half of all recalls (49.3%) in 2023 were related to allergens undeclared on packaging, while other major reasons for recalls were listeria contamination (15%), salmonella contamination (8.6%) and uninspected products (6.1%).</p>



<p>This uptick in undisclosed allergen cases was partially driven by the&nbsp;<a href="https://www.fda.gov/consumers/consumer-updates/allergic-sesame-food-labels-now-must-list-sesame-allergen#:~:text=As%20of%20January%201%2C%202023%2C%20sesame%20is%20required%20to%20be,milk" rel="noreferrer noopener" target="_blank">inclusion</a>&nbsp;of sesame—which accounted for 39% of the increase—as a required disclosed allergen, a rule that began in January 2023.</p>



<h2 class="wp-block-heading" id="h-what-are-the-5-biggest-food-recalls-of-2024-so-far">WHAT ARE THE 5 BIGGEST FOOD RECALLS OF 2024 SO FAR?</h2>



<ul>
<li><strong>Dairy products: </strong>An investigation into a “multi-year, multistate” <a href="https://www.forbes.com/sites/ariannajohnson/2024/02/08/costco-trader-joes-walmart-recall-dairy-products-over-listeria-outbreak-what-to-know/?sh=7902e28a47f5">listeria outbreak</a> was reopened after listeria was found in several food products containing dairy like queso fresco and cotija cheese. This outbreak includes cases dating back to 2014, and the FDA investigated it in 2017 and 2021, though it couldn’t link a specific brand to the outbreak. The most recent investigation was reopened in January, and manufacturer Rizo-Lopez Foods voluntarily recalled around <a href="https://www.fda.gov/media/176015/download?attachment" target="_blank" rel="noreferrer noopener">60</a> dairy products. Major retailers like Walmart, Costco and Trader Joe’s recalled products including salad and taco kits due to potential contamination. As of April 9, the FDA and Centers for Disease Control and Prevention <a href="https://www.fda.gov/food/outbreaks-foodborne-illness/outbreak-investigation-listeria-monocytogenes-queso-fresco-and-cotija-cheese-february-2024" target="_blank" rel="noreferrer noopener">report</a> the outbreak is over. The agencies said there were 26 cases, 23 hospitalizations and two deaths across 11 states.</li>



<li><strong>Trader Joe’s Dumplings: </strong>Over 61,000 pounds of Trader Joe’s steamed chicken soup dumplings were recalled in March due to potential hard plastic contamination from a permanent marker. The products were voluntarily recalled by manufacturer CJ Foods Manufacturing Beaumont Corporation, <a href="https://www.fsis.usda.gov/recalls-alerts/cj-foods-manufacturing-beaumont-corporation-recalls-trader-joes-chicken-soup" target="_blank" rel="noreferrer noopener">according</a> to the USDA. The problem was discovered after customers submitted complaints of hard plastics in their dumplings, though no adverse reactions were reported.</li>



<li><strong>Ground cinnamon: </strong>The FDA issued an <a href="https://www.fda.gov/food/alerts-advisories-safety-information/fda-alert-concerning-certain-cinnamon-products-due-presence-elevated-levels-lead" target="_blank" rel="noreferrer noopener">alert</a> in March warning it found unsafe levels of lead in six ground cinnamon products. These products were sold in discount stores like Dollar Tree and Family Dollar across several states. This recall came after the FDA investigated the recall of lead-tainted <a href="https://www.forbes.com/sites/ariannajohnson/2024/02/07/lead-poisoned-applesauce-ecuadorian-cinnamon-processor-likely-source-behind-recalled-pouches-fda-says/?sh=27a6e3082618">cinnamon applesauces</a> in 2023 that led to over 500 reports of adverse events in children.</li>



<li><strong>Trader Joe’s cashews: </strong>Wenders LLC, the manufacturer of the nuts, <a href="https://www.forbes.com/sites/caileygleeson/2024/03/18/trader-joes-cashews-recall-product-pulled-in-16-states-over-salmonella-concerns/?sh=3ac5e89e58d4">recalled</a> four lots of Trader Joe’s 50% Less Sodium Roasted &amp; Salted Whole Cashews in March due to potential salmonella contamination. Though no illnesses have been reported, the potentially contaminated nuts were sold in 16 states.</li>



<li><strong>Quaker Oats products: </strong>Quaker Oats <a href="https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/update-quaker-issues-revised-recall-notice-additional-products-due-possible-health-risk" target="_blank" rel="noreferrer noopener">expanded</a> its list of recalled products in January after it recalled several in December due to possible salmonella contamination. This expanded list included over 20 granola, protein and cereal bars, cereals, instant oatmeals and snack mixes sold in all 50 states. However, no adverse events have been reported.</li>
</ul>



<h2 class="wp-block-heading" id="h-big-number">BIG NUMBER</h2>



<p>48 million. That’s how many Americans the CDC&nbsp;<a href="https://www.cdc.gov/foodborneburden/2011-foodborne-estimates.html" rel="noreferrer noopener" target="_blank">estimates</a>&nbsp;get sick annually due to foodborne disease, totaling one out of six Americans. Out of that number, 128,000 are hospitalized and 3,000 die.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>Food gets recalled in one of four ways, according to the report. One way is consumers get sick, seek medical attention and then local officials or the CDC test fluids and trace an outbreak to a specific food item; another is consumers file a complaint with companies or regulators; a third is local, state or federal officials discover an issue through investigations or routine surveillance; and the other method is by companies self-reporting a problem after testing. The FDA regulates around&nbsp;<a href="https://www.fda.gov/media/143704/download" rel="noreferrer noopener" target="_blank">78%</a>&nbsp;of the country’s food supply, and its oversight includes everything except meat, poultry and some fish and eggs products, which are regulated by the USDA. The FDA was behind 224 recalls in 2023, while the USDA accounted for 89, according to the report. Although the number of recalls via the FDA were virtually unchanged, the number of USDA recalls increased by 31% in 2023 compared with 2022—the highest levels since 2019.</p>



<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2024/02/08/costco-trader-joes-walmart-recall-dairy-products-over-listeria-outbreak-what-to-know/?sh=7902e28a47f5">Costco, Trader Joe’s, Walmart Recall Dairy Products Over Listeria Outbreak—What To Know</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2024/02/07/lead-poisoned-applesauce-ecuadorian-cinnamon-processor-likely-source-behind-recalled-pouches-fda-says/?sh=27a6e3082618">Lead-Poisoned Applesauce: Ecuadorian Cinnamon Processor ‘Likely Source’ Behind Recalled Pouches, FDA Says</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/caileygleeson/2024/03/18/trader-joes-cashews-recall-product-pulled-in-16-states-over-salmonella-concerns/?sh=3ac5e89e58d4">Trader Joe’s Cashews Recall: Product Pulled In 16 States Over Salmonella Concerns</a>&nbsp;(Forbes)</p>


A Safeway Grocery Store Ahead Of Alberston’s Earnings Figures

2023 Had Most Food Recalls Since Start Of COVID-19 Pandemic, Report Finds


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>Researchers have potentially linked an antiviral protein produced by the body during infection as the cause of long Covid, according to a new study, and they’re optimistic the next step is making medications to treat the disease.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>Researchers followed patients with long Covid for 2.5 years to determine why some recovered from their symptoms and others didn’t, according to the study published Wednesday in Science Advances.</p>



<p>Long Covid (or post-Covid) symptoms include shortness of breath, loss of smell or taste, brain fog or chest pain following recovery from a Covid infection that can last for weeks—or in some cases, for years—<a href="https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html" target="_blank" rel="noreferrer noopener">according</a>&nbsp;to the Centers for Disease Control and Prevention.</p>



<p>When infected with the coronavirus, people produce an inflammatory protein called&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154595/" target="_blank" rel="noreferrer noopener">interferon gamma</a>&nbsp;(or IFN-y), which is part of the body’s natural response to fight off infection.</p>



<p>The production of the protein typically stops once infection goes away, but researchers discovered participants with ongoing Covid symptoms had high levels of IFN-y for up to 31 months after initial infection, which the researchers believe may be the cause of long Covid.</p>



<p>Over 60% of patients experienced relief from at least some of their symptoms during the study period, and participants who were vaccinated after infection saw significant decreases in their long Covid symptoms and IFN-y production, suggesting vaccination “improved” long Covid symptoms, according to the study.</p>



<p>Current long Covid treatment only targets symptom alleviation and not the underlying disease, but now that a potential cause has been identified, there’s “hope that this could help to pave the way” for creating medication to specifically target long Covid, and “give some patients a firm diagnosis,” Benjamin Krishna, the study’s co-author and an investigator at Cambridge University, said in a statement.</p>



<h2 class="wp-block-heading" id="h-crucial-quote">CRUCIAL QUOTE</h2>



<p>“The number of people with long Covid is gradually falling, and vaccination seems to be playing a significant role in that,” Krishna said. “But new cases are still cropping up, and then there is the big question of what happens when the next coronavirus pandemic comes along. Understanding what causes long Covid now could give us a crucial head start.”</p>



<h2 class="wp-block-heading" id="h-big-number">BIG NUMBER</h2>



<p>65 million. That’s how many people worldwide suffer from long Covid, according to a 2023&nbsp;<a href="https://www.nature.com/articles/s41579-022-00846-2" target="_blank" rel="noreferrer noopener">study</a>. The CDC&nbsp;<a href="https://www.cdc.gov/mmwr/volumes/72/wr/mm7232a3.htm?s_cid=mm7232a3_w" target="_blank" rel="noreferrer noopener">estimated</a>&nbsp;around 6% of American adults in June 2023 experienced long Covid at some point in their lives.</p>



<h2 class="wp-block-heading" id="h-what-to-watch-for">WHAT TO WATCH FOR</h2>



<p>The study researchers believe because there are several symptoms of long Covid that can look very different from each other, more research is needed in order to create subgroups of the disease. It’s “unlikely” all symptoms are caused by the same thing since some patients are able to recover while others aren’t, so future studies into why should be conducted, according to the researchers.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>Several risk factors play into who’s more susceptible to long Covid, <a href="https://covid19.nih.gov/covid-19-topics/long-covid" target="_blank" rel="noreferrer noopener">according</a> to the National Institutes of Health: underlying health conditions like obesity and diabetes, going unvaccinated, experiencing severe Covid infection or hospitalization, older age and being a woman are all risk factors. Long Covid can affect several organs and body systems like the heart, lungs, kidney, reproductive system and brain and also trigger other health conditions like kidney disease, autoimmune disorders or diabetes. Other experts have attempted to identify the cause of long Covid. Some <a href="https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01359-7" target="_blank" rel="noreferrer noopener">studies</a> have hypothesized tiny clots in the cells that persist for a long time may be the cause of some symptoms. The microclots may cause an inflammatory response, which causes exhaustion and fatigue, two of the most common long Covid symptoms. The Science Advances researchers believe their new findings suggest microclotting can’t be the only or most significant cause, though they don’t rule it out. The lowering of certain anti-inflammatory gut microbiomes during and after Covid—which causes an inflammatory response—may also trigger long Covid, according to a 2022 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088471/" target="_blank" rel="noreferrer noopener">study</a>. Another theory is that the coronavirus itself—not the body’s response to it—causes long Covid by damaging or altering cells, leading to lasting symptoms, according to a separate Science Advances <a href="https://www.science.org/doi/10.1126/sciadv.abc5801" target="_blank" rel="noreferrer noopener">paper</a>.</p>


A Covid-19 Vaccination Site As Children Under 5-Years Old Become Eligible For Shot

Possible Long Covid Cause Identified: Suggests Protein Might Be Culprit—And Medication Might Cure It


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>Covid vaccines from companies like Pfizer, Moderna and AstraZeneca were linked to rare occurrences of heart, brain and blood disorders, a recent peer-reviewed study found, though experts say the risks of developing Covid-19 greatly outweigh the risks of getting vaccinated.</p>



<h2 class="wp-block-heading">KEY FACTS</h2>



<p>Researchers from the Global Vaccine Data Network—a research arm of the World Health Organization—looked at expected versus observed rates of 13 medical conditions that were considered “adverse events of special interest” in a study population of 99 million vaccinated people eight countries, making it the largest Covid vaccine study to date.</p>



<p>Rare cases of <a href="https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.html#:~:text=Myocarditis%20is%20inflammation%20of%20the,Shortness%20of%20breath" target="_blank" rel="noreferrer noopener">myocarditis</a>—inflammation of the heart—were identified in the first, second and third doses of Pfizer-BioNTech’s and Moderna’s mRNA vaccines: The highest rate was seen after the second Moderna dose (6.1 times the expected rate of cases), according to the study published in the journal Vaccine.</p>



<p>Another heart condition called&nbsp;<a href="https://www.mayoclinic.org/diseases-conditions/pericarditis/symptoms-causes/syc-20352510#:~:text=Pericarditis%20is%20swelling%20and%20irritation,and%20goes%20away%20without%20treatment." target="_blank" rel="noreferrer noopener">pericarditis</a>&nbsp;had a 6.9-fold increased risk in those who took a third dose of AstraZeneca’s viral-vector vaccine, while a first and fourth dose of Moderna’s vaccine had a 1.7-fold and 2.6-fold increased risk, respectively.</p>



<p>There was a 2.5-times greater risk of developing the rare autoimmune disorder&nbsp;<a href="https://www.mayoclinic.org/diseases-conditions/guillain-barre-syndrome/symptoms-causes/syc-20362793" target="_blank" rel="noreferrer noopener">Guillain-Barre syndrome</a>&nbsp;among those who took AstraZeneca’s vaccine compared to the rate researchers expected, and a 3.2-times greater risk of getting blood clots among the same population.</p>



<p>There was a 3.8-times greater risk of developing the neurological disorder acute disseminated encephalomyelitis after the Moderna vaccine was administered, and a 2.2-fold increased risk after AstraZeneca’s vaccine, according to the study.</p>



<h2 class="wp-block-heading">BIG NUMBER</h2>



<p>13.5 billion. That’s how many Covid vaccines have been administered worldwide since the start of the Covid pandemic,&nbsp;<a href="https://ourworldindata.org/covid-vaccinations" target="_blank" rel="noreferrer noopener">according</a>&nbsp;to science research organization Our World in Data. Around 71% of the world’s population has received at least one dose of a Covid vaccine.</p>



<h2 class="wp-block-heading">CRUCIAL QUOTE</h2>



<p>“The odds of all of these adverse events is still much, much higher when infected with SARS-CoV-2 (COVID-19), so getting vaccinated is still by far the safer choice,” CEO of biotechnology company Centivax Jacob Glanville, who is not involved in the study, told Forbes.</p>



<h2 class="wp-block-heading">KEY BACKGROUND</h2>



<p>Covid vaccines are meant to prevent severe infection, and studies have indicated&nbsp;<a href="https://www.cdc.gov/vaccines/acip/recs/grade/covid-19-moderna-vaccine.html%5C" target="_blank" rel="noreferrer noopener">Moderna</a>,&nbsp;<a href="https://www.cdc.gov/vaccines/acip/recs/grade/covid-19-pfizer-biontech-vaccine.html" target="_blank" rel="noreferrer noopener">Pfizer-BioNTech</a>&nbsp;and&nbsp;<a href="https://www.who.int/news-room/feature-stories/detail/the-oxford-astrazeneca-covid-19-vaccine-what-you-need-to-know#:~:text=The%20AstraZeneca%20vaccine%20has%20an,about%204%20to%2012%20weeks." target="_blank" rel="noreferrer noopener">AstraZeneca’s</a>&nbsp;vaccines are effective at preventing severe illnesses, hospitalizations and death. Meanwhile, the chances of having a neurological event after a Covid infection were up to 617-fold higher than following COVID vaccination, which suggests “the benefits of vaccination substantially outweigh the risks,” according to the Vaccine study researchers. The risk of developing myocarditis is higher post-Covid infection than after getting a Covid vaccine,&nbsp;<a href="https://medicine.yale.edu/profile/akiko-iwasaki/" target="_blank" rel="noreferrer noopener">according</a>&nbsp;to Akiko Iwasaki, PhD, professor of Immunobiology at Yale University. Myocarditis risk after the second dose of a Covid vaccine is 35.9 per 100,000 people, compared to a 64.9 per 100,000 risk after Covid infection. The risk of developing Guillain-Barre syndrome after Covid infection was six times greater, and the risk of developing it after vaccination was 0.41 times greater than the control group, according to a 2023&nbsp;<a href="https://www.neurology.org/doi/10.1212/WNL.0000000000207900" target="_blank" rel="noreferrer noopener">study</a>&nbsp;published in Neurology. While most Americans have received at least one Covid-19 vaccine shot, uptake for booster shots that are updated to combat new coronavirus strains has remained slow.</p>



<h2 class="wp-block-heading">TANGENT</h2>



<p>The rapidly spreading Covid variant JN.1 caused an&nbsp;<a href="https://www.forbes.com/sites/roberthart/2023/12/20/jn1-covid-variant-of-interest-spreading-fast-in-us---heres-what-to-know/?sh=2fe82e10ccce">uptick in cases</a>&nbsp;during the fall and winter months, causing a resurgence of the tripledemic—when cases of Covid, flu and respiratory syncytial virus simultaneously increase. JN.1 made up&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions%5C" target="_blank" rel="noreferrer noopener">96.4</a><a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions" target="_blank" rel="noreferrer noopener">%</a>&nbsp;of all cases in the two week period ending in Feb. 17. However, Covid cases (down 0.6%) and deaths (down 6.9%) are&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#variants-genomic-surveillance" target="_blank" rel="noreferrer noopener">declining</a>—though hospitalizations are up 0.8%—signaling an&nbsp;<a href="https://www.forbes.com/sites/caileygleeson/2024/01/19/tripledemic-surge-eases-as-covid-rsv-flu-figures-drop-for-second-week/?sh=5b629a4c64ac">end</a>&nbsp;to the tripledemic. The variant was&nbsp;<a href="https://www.who.int/docs/default-source/coronaviruse/18122023_jn.1_ire_clean.pdf?sfvrsn=6103754a_3" target="_blank" rel="noreferrer noopener">classified</a>&nbsp;as a “variant of interest”—meaning it’s spreading in a way that may pose “an emerging risk to global public health”—by the World Health Organization in December. JN.1 is an offshoot of the highly mutated&nbsp;<a href="https://www.forbes.com/sites/ariannajohnson/2023/11/28/what-to-know-about-rapidly-spreading-pirola-covid-variant-ba286-and-if-vaccines-offer-protection/?sh=27f10c0e1978">Pirola</a>&nbsp;(BA.2.86) virus that some experts worried wouldn’t be protected against the updated monovalent Covid boosters, which specifically target XBB variants. However, vaccine makers ensured their shots provided some protection.</p>



<h2 class="wp-block-heading">FURTHER READING</h2>



<p><a href="https://www.forbes.com/sites/roberthart/2023/12/20/jn1-covid-variant-of-interest-spreading-fast-in-us---heres-what-to-know/?sh=2fe82e10ccce">JN.1 Covid ‘Variant Of Interest’ Spreading Fast In U.S. — Here’s What To Know</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/caileygleeson/2024/01/19/tripledemic-surge-eases-as-covid-rsv-flu-figures-drop-for-second-week/?sh=5b629a4c64ac">‘Tripledemic’ Surge Eases As Covid, RSV, Flu Figures Drop For Second Week</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2023/11/28/what-to-know-about-rapidly-spreading-pirola-covid-variant-ba286-and-if-vaccines-offer-protection/?sh=717483311978">What To Know About Rapidly Spreading ‘Pirola’ Covid Variant BA.2.86—And If Vaccines Offer Protection</a>&nbsp;(Forbes)</p>


Japan begins the third inoculation of COVID-19 vaccine

Covid Vaccines Linked To Small Increase In Heart And Brain Disorders, Study Finds—But Risk From Infection Is Far Higher


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>Hospitalizations for Covid spiked 20% in the week after Christmas, according to new <a href="https://covid.cdc.gov/covid-data-tracker/#datatracker-home" target="_blank" rel="noreferrer noopener">data</a> from Centers for Disease Control and Prevention, along with an increase in Covid deaths, and flu hospitalizations and deaths, solidifying what experts predicted to be a “severe” season for respiratory illnesses as Americans traveled and gathered for holiday celebrations.</p>



<h2 class="wp-block-heading">KEY FACTS</h2>



<p>There were 34,798 Covid-related hospitalizations during the holiday week ending in Dec. 30, 2023, a 20.4% increase from the week prior, according to&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#datatracker-home" target="_blank" rel="noreferrer noopener">data</a>&nbsp;from Centers for Disease Control and Prevention.</p>



<p>Covid-related deaths were up <a href="https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths" target="_blank" rel="noreferrer noopener">12.5%</a> during this period, with the highest concentrations in New Jersey, Massachusetts, Missouri and Oklahoma.</p>



<p>New Omicron Covid variant JN.1 made up&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions" target="_blank" rel="noreferrer noopener">61.6%</a>&nbsp;of all Covid cases in the two-week period between Dec. 24, 2023 and January 6, up 22.8% from the previous two-week period.</p>



<p>There were&nbsp;<a href="https://www.cdc.gov/flu/weekly/index.htm#ORIAM" target="_blank" rel="noreferrer noopener">39 states</a>&nbsp;with high or very high levels for respiratory illness, including Covid, the flu and respiratory syncytial virus—this is up from 34 states the previous week.</p>



<p>Flu cases increased by <a href="https://www.cdc.gov/flu/weekly/index.htm" target="_blank" rel="noreferrer noopener">17.5%</a>, and there were <a href="https://www.cdc.gov/flu/weekly/index.htm#NHSN" target="_blank" rel="noreferrer noopener">20,066</a> flu-related hospitalizations, up over 5% from the previous week, according to the CDC.</p>



<h2 class="wp-block-heading">KEY BACKGROUND</h2>



<p>Doctors at Cedars-Sinai Hospital in Los Angeles&nbsp;<a href="https://www.cedars-sinai.org/newsroom/preparing-for-a-tripledemic-holiday-season/" target="_blank" rel="noreferrer noopener">warned</a>&nbsp;in November 2023 that experts were preparing for an intense tripledemic holiday season. “It’s going to be a severe respiratory virus season,” associate director of Hospital Epidemiology at Cedars-Sinai, said in a statement. The tripledemic is a simultaneous rise in Covid, flu and RSV cases, which typically peaks during the winter season each year. Because of an uptick in respiratory illness-related hospitalizations, several healthcare systems across the country have reinstated&nbsp;<a href="https://www.forbes.com/sites/ariannajohnson/2024/01/04/heres-where-mask-mandates-are-coming-back-as-covid-cases-and-hospitalizations-rise/?sh=6e54ea132542">mask mandates</a>. Healthcare facilities in New York City began requiring masks for all patients, visitors and staff earlier this week. After the Illinois Department of Public advised hospitals to increase their mitigation efforts in December, several hospitals reinstated mask mandates, including Chicago-based Rush University Medical Center, Cook County Health and Endeavor Health. Berkshire Health System in Massachusetts began requiring masks on Wednesday, citing a “<a href="https://www.berkshirehealthsystems.org/news/winter-respiratory-viruses-on-the-rise-bhs-reinstitutes-masking-and-updates-visitor-guidelines" target="_blank" rel="noreferrer noopener">significant increase</a>” in local respiratory cases. After Los Angeles County entered the&nbsp;<a href="http://publichealth.lacounty.gov/acd/ncorona2019/masks/" target="_blank" rel="noreferrer noopener">medium level</a>&nbsp;for Covid hospitalizations last month, the county required masks in all its hospitals.</p>



<h2 class="wp-block-heading">TANGENT</h2>



<p>New Covid variant JN.1 has been driving an increase in Covid cases across the country as it’s been rapidly spreading. JN.1 only made up&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions" target="_blank" rel="noreferrer noopener">3.3%</a>&nbsp;of all Covid cases during the two-week period ending in Nov. 11, 2023, so it’s grown by almost 60% in a little over two months. The World Health Organization&nbsp;<a href="https://www.forbes.com/sites/roberthart/2023/12/20/jn1-covid-variant-of-interest-spreading-fast-in-us---heres-what-to-know/?sh=4fafa4dc10cc">classified</a>&nbsp;it as a “variant of interest” in December 2023, meaning it’s spreading in a way that may pose “an emerging risk to global public health.” JN.1 is an offshoot of the highly mutated&nbsp;<a href="https://www.forbes.com/sites/ariannajohnson/2023/11/28/what-to-know-about-rapidly-spreading-pirola-covid-variant-ba286-and-if-vaccines-offer-protection/?sh=27f10c0e1978">Pirola</a>&nbsp;(BA.2.86) strain that was spreading rapidly last fall. Some healthcare experts worried Pirola wouldn’t be protected against the updated monovalent Covid vaccines since they specifically target XBB variants. However, Moderna, Novavax and Pfizer-BioNTech said their shots provided some protection. Because of how rapidly JN.1 spread, the CDC&nbsp;<a href="https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html" target="_blank" rel="noreferrer noopener">said</a>&nbsp;it was the “fastest growing variant in the United States.” WHO also&nbsp;<a href="https://www.who.int/docs/default-source/coronaviruse/18122023_jn.1_ire_clean.pdf?sfvrsn=6103754a_3" target="_blank" rel="noreferrer noopener">acknowledged</a>&nbsp;JN.1’s growth, stating it made up the majority of all BA.2.86 subvariants circulating globally, though available evidence suggested it posed a low risk to public health.</p>



<h2 class="wp-block-heading">FURTHER READING</h2>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2024/01/04/heres-where-mask-mandates-are-coming-back-as-covid-cases-and-hospitalizations-rise/?sh=6e54ea132542">Here’s Where Mask Mandates Are Coming Back As Covid Cases And Hospitalizations Rise</a>&nbsp;(Forbes)</p>



<p><a href="https://www.cedars-sinai.org/newsroom/preparing-for-a-tripledemic-holiday-season/" target="_blank" rel="noreferrer noopener">Preparing for a ‘Tripledemic’ Holiday Season</a>&nbsp;(Cedars-Sinai)</p>



<p><a href="https://www.forbes.com/sites/roberthart/2023/12/20/jn1-covid-variant-of-interest-spreading-fast-in-us---heres-what-to-know/?sh=4fafa4dc10cc">JN.1 Covid ‘Variant Of Interest’ Spreading Fast In U.S. — Here’s What To Know</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2023/11/28/what-to-know-about-rapidly-spreading-pirola-covid-variant-ba286-and-if-vaccines-offer-protection/?sh=1493441c1978">What To Know About Rapidly Spreading ‘Pirola’ Covid Variant BA.2.86—And If Vaccines Offer Protection</a>&nbsp;(Forbes)</p>


TUNISIA-HEALTH-VIRUS-TOURISM-HOSPITAL

Covid Hospitalizations And Deaths See Double-Digit Spike After Holiday — Amid Surge In Respiratory Illnesses


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>The World Health Organization said it is tracking a new coronavirus “variant of interest” called JN.1, an offshoot of the highly mutated “Pirola” strain that is spreading rapidly around the world and has become the fastest growing variant in the United States.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>JN.1 is an offshoot of the highly mutated omicron variant BA.2.86, often given the nickname “<a href="https://www.forbes.com/sites/roberthart/2023/09/06/modernas-updated-covid-vaccine-is-effective-against-pirola-variant-as-concern-over-new-strain-grows/?sh=6dd42d971a06">Pirola</a>,” which some experts&nbsp;<a href="https://www.forbes.com/sites/ariannajohnson/2023/11/28/what-to-know-about-rapidly-spreading-pirola-covid-variant-ba286-and-if-vaccines-offer-protection/?sh=5d1849481978">worried</a>&nbsp;could&nbsp;<a href="https://www.theguardian.com/world/2023/sep/08/pirola-latest-covid-variant-spreading-in-uk-health-data-suggests" target="_blank" rel="noreferrer noopener">evade</a>&nbsp;protection from prior infections and vaccination and trigger a large wave of disease like the original omicron variant did when it emerged.</p>



<p>As the WHO already classified BA.2.86 a “variant of interest”—a strain of virus with genetic changes known or believed to affect traits like transmissibility, immune escape and disease severity and that is spreading in a way that could pose “an emerging risk to global public health”—and tracked JN.1 as part of this group, it was already considered to be a “variant of interest” anyway.</p>



<p>The WHO&nbsp;<a href="https://www.who.int/docs/default-source/coronaviruse/18122023_jn.1_ire_clean.pdf?sfvrsn=6103754a_3" target="_blank" rel="noreferrer noopener">said</a>&nbsp;JN.1 now merits its own standalone classification on account of its “rapidly increasing spread” around the world, adding that it now makes up the “vast majority” of BA.2.86 descendents reported.</p>



<p>The UN agency stressed available evidence, while “limited,” suggests the strain poses a “low” risk to public health.</p>



<p>That assessment was&nbsp;<a href="https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html" target="_blank" rel="noreferrer noopener">echoed</a>&nbsp;by the Centers for Disease Control and Prevention in early December, when the agency said the JN.1 variant was responsible for between 15% and 29% of Covid cases and was the “fastest-growing variant in the United States.”</p>



<p>Both health agencies said updated booster vaccines will continue to protect against severe disease and death from JN.1, as they do for other variants, and that there is no sign the strain causes more severe disease compared to other variants.</p>



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<h2 class="wp-block-heading" id="h-what-we-don-t-know">WHAT WE DON’T KNOW</h2>



<p>“The continued growth of JN.1 suggests that it is either more transmissible or better at evading our immune systems,” the CDC said in early December. However, the agency said it’s not clear how much JN.1 is contributing to the recent uptick in Covid activity given patterns of infection normally observed this time of year. It’s also not clear whether JN.1 produces a different set of symptoms to other variants, the CDC said, noting that symptoms “tend to be similar across variants.” Severity and types of symptoms “usually depend more on a person’s immunity and overall health rather than which variant causes the infection,” the agency said. The CDC said it will continue monitoring the situation and that Covid activity is likely to increase over the month of December, urging people to get vaccinated “if you haven’t received one this fall.”</p>



<h2 class="wp-block-heading" id="h-news-peg">NEWS PEG</h2>



<p>JN.1 is on&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions" target="_blank" rel="noreferrer noopener">track</a>&nbsp;to become the dominant variant in the U.S. in a matter of weeks. The agency’s latest projections estimate the variant was responsible for up to 30% of cases as of December 9, up from between 6% and 11% two weeks earlier. It trails dominant variant HV.1, which was responsible for an estimated 27% to 33% of cases as of December 9 and 30% to 34% of cases two weeks before that. In the CDC region covering the Northeast—New Jersey, New York, Puerto Rico and the Virgin Islands—JN.1 is already the dominant variant and responsible for an estimated 32% of cases. The variant is on a steep upward trajectory in other areas as well and is responsible for between 15% and 26% of cases in regions monitored by the CDC.</p>



<h2 class="wp-block-heading" id="h-big-number">BIG NUMBER</h2>



<p>1,159,864. That’s how many Covid deaths there have been in the U.S. since January 2020,&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#datatracker-home" target="_blank" rel="noreferrer noopener">according</a>&nbsp;to CDC data. Since early September, there have been around 1,200 to 1,400 Covid deaths across the country each week, some of the lowest figures since the pandemic began and down from a peak of nearly 26,000 around the start of 2021 when omicron drove a wave of cases.</p>



<h2 class="wp-block-heading" id="h-what-to-watch-for">WHAT TO WATCH FOR</h2>



<p>There is another category that sits above the WHO’s “variant of interest” class that the organization has not used since the emergence of omicron. The “variant of concern” threshold, which would likely secure the variant a Greek letter moniker like alpha, beta or delta, is reserved for strains that pose a significantly increased risk to public health. Such variants would have been shown to be more contagious, cause more severe disease or escape the protection of vaccines and treatments.</p>



<h2 class="wp-block-heading" id="h-tangent">TANGENT</h2>



<p>The CDC&nbsp;<a href="https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html" target="_blank" rel="noreferrer noopener">said</a>&nbsp;JN.1 is still closely related to BA.2.86, despite what the differences in name suggest. The difference comes down to how variants are named, the CDC said, and explained that “there is only a single change between JN.1 and BA.2.86 in the spike protein.” The spike protein is an important part of the coronavirus that allows the virus to enter cells and cause infection.</p>



<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://www.forbes.com/sites/roberthart/2023/09/06/modernas-updated-covid-vaccine-is-effective-against-pirola-variant-as-concern-over-new-strain-grows/?sh=6dd42d971a06">Moderna’s Updated Covid Vaccine Is Effective Against Pirola Variant—As Concern Over New Strain Grows</a>&nbsp;(Forbes)</p>


Netherlands Reimposes Partial Lockdown Amid Latest Covid-19 Wave

JN.1 Covid ‘Variant Of Interest’ Spreading Fast In U.S. — Here’s What To Know


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>The Federal Aviation Administration on Wednesday <a href="https://www.faa.gov/space/stakeholder_engagement/spacex_starship" target="_blank" rel="noreferrer noopener">granted a license</a> to billionaire Elon Musk’s SpaceX for its highly anticipated second launch of its Starship rocket, clearing the way for a test flight as soon as this week, after more than six months being grounded since its previous launch ended in a <a href="https://www.forbes.com/sites/anafaguy/2023/04/20/spacex-starship-explodes-after-launch/?sh=670a7bb36645">fiery explosion</a>.\</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>SpaceX’s Starship, an ambitious program intended to eventually take passengers to the moon and Mars, has met “all safety, environmental, policy and financial responsibility requirements,” the FAA determined.</p>



<p>The FAA’s approval gives SpaceX the go-ahead for a second launch at its Boca Chica launch site in Cameron County, Texas, south of Corpus Christi.</p>



<p>In a post on X, formerly known as Twitter, SpaceX said it plans to conduct the launch between 7 a.m. and 9 a.m. local time on Friday.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>In April, a SpaceX rocket that had been scheduled to travel 150 miles into Earth’s atmosphere suddenly exploded several minutes after take-off, which SpaceX called a “rapid unscheduled disassembly before stage separation.” SpaceX initially planned its next test launch “in a few months,” Musk—who also owns X and Tesla—said in a&nbsp;<a href="https://twitter.com/elonmusk/status/1649050306943266819" target="_blank" rel="noreferrer noopener">post</a>&nbsp;on his social media platform. SpaceX also&nbsp;<a href="https://twitter.com/SpaceX/status/1649045802332073986" target="_blank" rel="noreferrer noopener">said</a>&nbsp;April’s test, despite its explosion, “will help us improve Starship’s reliability.” The FAA was later sued by a group of environmental and cultural heritage organizations, who alleged the agency erred in its approval of the test launch and that its approval violated federal environmental law.&nbsp;<a href="https://www.forbes.com/sites/brianbushard/2023/05/01/faa-sued-over-spacex-starship-explosion/?sh=39c6f88679de">Plaintiffs argued</a>&nbsp;the FAA failed to conduct a full environmental review and did not require SpaceX to mitigate potential environmental harm.</p>



<h2 class="wp-block-heading" id="h-tangent">TANGENT</h2>



<p>NASA partnered with SpaceX in April 2021 to develop a landing system to take astronauts to the moon for the space agency’s Artemis III mission, another program aimed at bringing astronauts back to the moon for the first time in more than 50 years.</p>



<h2 class="wp-block-heading" id="h-surprising-fact">SURPRISING FACT</h2>



<p>At 400 feet tall, the Starship rocket is the&nbsp;<a href="https://www.space.com/elon-musk-shows-off-starship-sn20-super-heavy-stack-february-2022" target="_blank" rel="noreferrer noopener">tallest and most powerful</a>&nbsp;rocket ever built.</p>



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<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://www.forbes.com/sites/anafaguy/2023/04/20/spacex-starship-explodes-after-launch/?sh=670a7bb36645">SpaceX Starship Explodes After Launch</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/jamiecartereurope/2023/04/08/elon-musks-spacex-is-about-to-launch-starship-into-orbit-around-earth/?sh=4dc7196b1ce1">Elon Musk’s SpaceX Is About To Launch ‘Starship’ Into Orbit Around Earth</a>&nbsp;(Forbes)</p>


A SpaceX Falcon 9 rocket launches the third pair of O3b

SpaceX Cleared For Second Starship Test Flight—After First Exploded


<p><strong>The UNICEF has secured a four-year supply of the newly WHO-approved R21/Matrix-M vaccine that could revolutionize malaria prevention, especially in Africa where 90% of fatalities occur.</strong></p>



<p>Malaria, one of the most widely-known parasitic diseases to mankind, takes the life of a child every minute according to World Health Organization (WHO) estimates, with almost 620,000 deaths per year. A staggering 241 million people contract the disease annually, illustrating the global scope of this public health crisis.</p>



<p>Now, a new vaccine has joined the world in the fight against the disease, having obtained WHO approval earlier this month. The United Nations Children&#8217;s Fund (UNICEF) has entered into an agreement to procure a four-year supply of the newly approved R21/Matrix-M vaccine from mid-2024.</p>



<p>The new vaccine is a product of over 35 years of vaccine research, a collaboration between the University of Oxford and the Serum Institute of India, notable in that it is only the second malaria vaccine approved for public use. The first, known as RTS,S, initiated the ground-breaking work in this field but was less efficacious.</p>



<p>Dubbed R21/Matrix-M, it is the first to surpass a 75% efficacy rate, providing protection of up to two years against symptomatic malaria with a single booster – which could be a ground-breaking shift in the fight to eradicate the disease, particularly on the African continent, where some 90% of the fatalities from the illness occur.</p>



<p>&#8220;It is heartbreaking and unacceptable that almost half a million children die of malaria every year. This agreement is a critical step towards protecting more children from this deadly disease,&#8221; said Director of UNICEF Supply Division Leila Pakkala in a press statement announcing the signing of UNICEF&#8217;s supply agreement.</p>



<p>The obtaining of the WHO&#8217;s endorsement earlier this month was critical to allow international bodies such as UNICEF to begin procuring the vaccines, with WHO having vetted the safety profile and efficacy of R21/Matrix-M.</p>



<p>Adar Poonawalla, CEO of the Serum Institute of India, commemorated the WHO endorsement in a press release: &#8220;For far too long, malaria has threatened the lives of billions of people across the globe, disproportionately affecting the most vulnerable amongst us. This is why the WHO recommendation and approval of the R21/Matrix-MTM vaccine marks a huge milestone on our journey to combat this life-threatening disease.&#8221;</p>



<p>The Serum Institute of India has already begun to prepare the production capability to deliver up to 100 million doses per year, to be doubled in the coming two years.</p>



<p><strong>Cost and Delivery</strong></p>



<p>Critically, for a vaccine that aims to prevent severe disease primarily in lower-income countries, the R21/Matrix-M is expected to cost only between $2 and $4 per dose, with an initial regimen consisting of one dose every month for three months, and one booster within the next 12 months – meaning that a full treatment protocol offering high levels of protection for almost two years costs less than $16.</p>



<p>Countries have already begun to factor in the new vaccine into their epidemiological planning, with both Ghana and Nigeria having obtained approval for the vaccine&#8217;s use – Ghana too has begun establishing a vaccine factory in Accra for this purpose in collaboration with the Serum Institute of India.</p>



<p><strong>The Path Forward</strong></p>



<p>Despite the leaps in vaccine development, challenges persist. While vaccines like R21/Matrix-M are revolutionary, they are not the final answer to a disease as complex and historically persistent as malaria. In the interim, nations continue to deploy traditional methods like insecticides, improved housing, and swamp drainage, especially in regions where malaria remains prevalent. It&#8217;s also worth mentioning that mRNA technology, catalyzed by COVID-19 research, holds the promise of even more effective vaccines in the future.</p>



<p>Global efforts have already made significant strides; the WHO reports a 90% decline in malaria mortality rates in the 20th century, but with many in the world still suffering under high rates of the disease, the new vaccine could be key in reducing fatalities in the years to come.</p>


R21-Vaccination (11 of 20); image credit University of Oxford, Tom Wilkinson

The Vaccine That Could Turn The Tide On Malaria In Africa, Where The Disease Is One Of The Biggest Killers


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>The Food and Drug Administration gave&nbsp;<a href="https://www.fda.gov/vaccines-blood-biologics/coronavirus-covid-19-cber-regulated-biologics/novavax-covid-19-vaccine-adjuvanted#:~:text=Novavax%20COVID-19%20Vaccine%2C%20Adjuvanted%20is%20available%20under%20emergency%20use,years%20of%20age%20and%20older" target="_blank" rel="noreferrer noopener">emergency use authorization</a>&nbsp;on Tuesday to Novavax’s new Covid vaccine designed to target the coronavirus’ dominant XBB sublineage, which is fueling a spike in cases, hospitalizations and deaths across the country.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>At&nbsp;<a href="https://www.ama-assn.org/delivering-care/public-health/updated-covid-vaccine-who-should-get-it-and-when-it-will-be-available" target="_blank" rel="noreferrer noopener">$130</a>&nbsp;a dose, the vaccine was approved for those 12 years and older—for those already vaccinated with any vaccine, one dose can be given at least two months after a person’s last Covid shot, and two doses administered three months apart can be given to the unvaccinated.</p>



<p>Novavax’s approval follows the&nbsp;<a href="https://www.forbes.com/sites/willskipworth/2023/09/11/fda-approves-new-covid-vaccines-to-target-latest-strains/?sh=1be38e906e09">approval</a>&nbsp;of Moderna and Pfizer-BioNTech’s monovalent vaccines targeting new coronavirus variant, which were also given emergency use authorization last month by the FDA for those six months and older.</p>



<p>This comes after the agency&nbsp;<a href="https://www.fda.gov/media/169591/download?attachment" target="_blank" rel="noreferrer noopener">encouraged</a>&nbsp;Moderna, Pfizer and Novavax to create new monovalent vaccines that target the XBB lineage, which makes up the majority of the variants circulating in the U.S.</p>



<p>The Novavax vaccine&nbsp;<a href="https://ir.novavax.com/press-releases/US-CDC-and-Advisory-Committee-Recommend-Use-of-Authorized-and-Approved-2023-2024-Monovalent-XBB-COVID-19-Vaccines" target="_blank" rel="noreferrer noopener">received approval</a>&nbsp;from an advisory committee of the Centers for Disease Control and Prevention last month, though it still awaits approval from the agency’s director.</p>



<p>This is the first time since the shots were commercialized that they won’t be free, and both&nbsp;<a href="https://apnews.com/article/science-health-business-covid-medicare-1a5d65356ebc7b5bc76524ae99deb55e" target="_blank" rel="noreferrer noopener">Pfizer</a>&nbsp;and&nbsp;<a href="https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-expects-price-its-covid-vaccine-about-130-us-2023-03-20/" target="_blank" rel="noreferrer noopener">Moderna</a>&nbsp;estimate their shots will cost between $110 and $130 a dose.</p>



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<p>Though most insurance companies are expected to cover the cost of Covid boosters, the CDC’s&nbsp;<a href="https://www.hhs.gov/about/news/2023/07/13/cdc-launch-bridge-access-program-fall-2023-provide-free-covid-19-vaccines-treatments-uninsured-underinsured-adults.html" target="_blank" rel="noreferrer noopener">Bridge Program</a>&nbsp;is set to launch this fall, providing Covid vaccine coverage to the uninsured.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>Covid-related deaths and hospitalizations have increased since the start of the summer and are expected to keep rising as fall and winter kick into gear. Deaths increased by 8% between September 17 and September 23, and hospitalizations stood at 19,079 during this period, according to the CDC’s most recent data. EG.5, or the “Eris” variant—part of the XBB lineage—is the dominant strain in the U.S., making up 29.4% of all cases between September 17 and September 30. As of June, the XBB omicron subvariants made up 95% of all Covid cases in the U.S., according to an FDA&nbsp;<a href="https://www.fda.gov/media/169591/download?attachment" target="_blank" rel="noreferrer noopener">report</a>. The existing bivalent boosters offer about 50% protection against XBB variants in most adults and about 33% protection in those 65 years and older, according to a January&nbsp;<a href="https://www.cdc.gov/mmwr/volumes/72/wr/mm7205e1.htm?s_cid=mm7205e1_w" target="_blank" rel="noreferrer noopener">study</a>&nbsp;conducted by the CDC. Moderna&nbsp;<a href="https://investors.modernatx.com/news/news-details/2023/Moderna-Clinical-Trial-Data-Confirm-Its-Updated-COVID-19-Vaccine-Generates-Robust-Immune-Response-in-Humans-Against-Widely-Circulating-Variants/default.aspx" target="_blank" rel="noreferrer noopener">said</a>&nbsp;its new booster may be effective at protecting against the Eris variant, Novavax&nbsp;<a href="https://www.cnbc.com/2023/08/22/covid-novavax-vaccine-eris-variant.html" target="_blank" rel="noreferrer noopener">said</a>&nbsp;its shot provided a broad immune response against Eris in small animals and Pfizer&nbsp;<a href="https://www.reuters.com/business/healthcare-pharmaceuticals/pfizers-updated-covid-shot-effective-against-eris-variant-mice-study-2023-08-17/" target="_blank" rel="noreferrer noopener">reported</a>&nbsp;its new shot protected against the variant when tested on mice. Because the current bivalent boosters don’t specifically protect against XBB, some experts&nbsp;<a href="https://www.forbes.com/sites/ariannajohnson/2023/08/21/new-covid-boosters-expected-this-fall-why-some-doctors-suggest-holding-off-on-getting-your-next-booster-until-then/?sh=447d21af438b">recommend</a>&nbsp;waiting until the new monovalent boosters release before getting an updated shot.</p>



<h2 class="wp-block-heading" id="h-contra">CONTRA</h2>



<p>An earlier round of updated Covid boosters provided additional protection against previous variants, but only&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#vaccination-states-jurisdictions" target="_blank" rel="noreferrer noopener">17%</a>&nbsp;of the U.S. has received at least one booster.</p>



<h2 class="wp-block-heading" id="h-tangent">TANGENT</h2>



<p>A new Covid variant called BA.2.86, or “Pirola,” is a descendant of the BA sublineage and has begun circulating in the U.S. Although there aren’t enough cases for it to appear on the CDC’s variant tracker, the World Health Organization has&nbsp;<a href="https://twitter.com/WHO/status/1692255671687794902" target="_blank" rel="noreferrer noopener">labeled</a>&nbsp;it as a variant under monitoring. This is because Pirola has 36 more&nbsp;<a href="https://slides.com/jbloom/new_2nd_gen_ba2_variant?ftag=YHF4eb9d17#/3" target="_blank" rel="noreferrer noopener">mutation spikes</a>&nbsp;than XBB.1.5—the dominant strain in the U.S. earlier this year—and 34 additional mutations compared to BA.2. Pirola isn’t a descendant of the XBB sublineages, so there may be concern they won’t protect against Pirola. However, Moderna&nbsp;<a href="https://www.forbes.com/sites/roberthart/2023/09/06/modernas-updated-covid-vaccine-is-effective-against-pirola-variant-as-concern-over-new-strain-grows/?sh=3f334501a06c">said</a>&nbsp;Wednesday its new booster provided an 8.7-fold increase in neutralizing antibodies against Pirola in its clinical trial.</p>



<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://www.nbcnews.com/health/health-news/fda-green-light-new-covid-boosters-early-friday-rcna103379" target="_blank" rel="noreferrer noopener">FDA could green light new Covid boosters as early as Friday</a>&nbsp;(NBC)</p>



<p><a href="https://www.forbes.com/sites/roberthart/2023/09/06/modernas-updated-covid-vaccine-is-effective-against-pirola-variant-as-concern-over-new-strain-grows/?sh=3f334501a06c">Moderna’s Updated Covid Vaccine Is Effective Against Pirola Variant—As Concern Over New Strain Grows</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2023/08/21/new-covid-boosters-expected-this-fall-why-some-doctors-suggest-holding-off-on-getting-your-next-booster-until-then/?sh=447d21af438b">New Covid Boosters Expected This Fall: Why Some Doctors Suggest Holding Off On Getting Your Next Booster Until Then</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2023/09/01/its-ok-to-get-your-covid-flu-and-rsv-shots-at-the-same-time-experts-say/?sh=486139df3099">It’s Okay To Get Your Covid, Flu And RSV Shots At The Same Time, Experts Say</a>&nbsp;(Forbes)</p>


Vaccinations at Egoli Township as Omicron Cases Spread

FDA Approves Novavax’s New Covid Vaccine Designed To Protect Against The Latest Strain


<p>&#8216;Sustained crisis’. I came across this terminology in a <em>Harvard Business Review </em>article recently, and it immediately struck a chord with my struggles running my company and also with what I see in the world around me.</p>



<p>The Covid-19 pandemic was a global crisis that came out of the blue, and we were all in it together. It did not matter which country we lived in or what our backgrounds were. It was a common fight.</p>



<p>But post-pandemic, we are dealing with a world that has become economically volatile for varying reasons, and it is becoming clearer that each country will first protect its own people and its own interests. Likewise, it has hit the interdependence of certain structures with a fragility like never before. And this has not abated since 2020.</p>



<p>For countries that are largely donor-dependent for their development needs and for humanitarian aid spending, vulnerabilities have increased. The aid narrative comes with its own politics and interests.</p>



<p>Several studies point to the fact that foreign aid is not as generous as it used to be.</p>



<p>In 2022, Ukraine accounted for a large chunk of foreign aid. And now many donor countries are facing pressures of their own from the post Covid-19 economic downturn to geopolitical vulnerabilities and political instabilities that have persisted over a long time.</p>



<p>Developing economies struggle with unsustainable debt burdens, rising food costs and liquidity crises. It is estimated by the World Bank that 7% of the world’s population will still be living in poverty by 2030.</p>



<p>For entrepreneurs in many countries, the ecosystem has changed significantly. Inflation persists and markets continue to shrink. Doing business has become costlier and more complex and negotiating the scale of challenges more difficult.</p>



<p>With increased advanced technological interface in business operations, the ecosystem demands a different resilience that government and business leaders must adopt and adapt to at a faster pace.</p>



<p>The common man is forced to navigate his needs confronted with higher prices, declining savings, more borrowing and employment loss. </p>



<p>In Nepal, where I am, the middle- and lower-income demographic is struggling with job cuts, unpaid salaries, cutdown on consumer expenditure and access to loans. There is a relentless outflow of Nepali youth entering the international labor market. The country’s central bank macroeconomic report shows that in the first 10 months of the current fiscal year, the government has issued permits for over 660,000 Nepalis to work abroad. This number excludes Nepalis going to India for work and the migration of students. </p>



<p>When young people see no future to build their lives in their country, it hurts the productivity and pride of the nation; but there is nothing to hold them back.</p>



<p>A crisis response is effective within a contained timeframe but when there is a prolonged state of crisis, the response needs to be inspired by a wider and more inclusive approach.</p>



<p>I ask what then is the lifeblood that will enable countries to navigate what is now a sustained crisis? Can countries do it alone?</p>



<p>Does this mark the departure of multilateralism? Why are the terms ‘deglobalization’ and ‘dedollarization’ increasingly making the rounds of panel discussions and economic reports?</p>



<p>The lifeblood perhaps lies in our ability to pause, reflect and continue. I believe that sustained crisis can only be overcome by sustained action. However, action must come from deeper values of integrity, innovation and compassion in the unfolding world order. It requires leaders – government and business – to be focused, flexible and decisive. Economic growth and social progress must be given equal emphasis. It requires citizens across the world to be more aware about their choices and actions. This is, perhaps, each one’s obligation and opportunity to create a meaningful world.</p>



<p><em><strong>A writer-photographer from Nepal who keeps the values of freedom and compassion at the core of her work</strong></em></p>


Kathmandu, city view

‘Sustained Crisis Can Only Be Overcome By Sustained Action’


<p><strong>Hydrogen powered fuel-cell electric vehicles (FCEVs) are extremely rare. BMW plans to bring a small fleet of iX5 Hydrogen cars to South Africa in 2024 to gauge interest with government representatives, thought leaders and potential customers. We got a sneak preview of the car at the IAA Mobility 2023 show in Munich.</strong></p>



<p>The world’s largest hydrogen-powered mining vehicle was launched in South Africa by multi-national mining company Anglo American in 2022. The prototype mine haul hybrid truck uses 2MW of hydrogen fuel cells to carry 290-tonnes, designed specifically for mining conditions at Mogalakwena Mine, the world’s largest platinum mine, in the country’s Limpopo province.</p>



<p>At the launch, President Cyril Ramaphosa called it a historic event not because of the impressive piece of machinery, but for being the “genesis of an entire ecosystem powered by hydrogen”.</p>



<p>“This is a gigantic leap for South Africa’s hydrogen future economy,” said Ramaphosa.</p>



<p>Fast forward to the Festival of Motoring in Johannesburg in August this year, when BMW showcased a unique vehicle flown in from its global fleet: an iX5 Hydrogen vehicle.</p>



<p>The display drew lots of attention from visitors. Peter van Binsbergen, the head of BMW Group South Africa, said there were many discussions locally about just energy transition, and with its trial fleet of the vehicle, it would contribute to the development of the hydrogen economy.</p>



<p>“I feel that a country like South Africa, and indeed a continent like Africa, has the ideal conditions to be a leader in generating green hydrogen for industrial and automotive applications,” said van Binsbergen.</p>



<p>In partnership with the South African government and other entities, Anglo American conducted a hydrogen valley feasibility study to identify three potential hubs in the cities of Johannesburg and Durban, and in Limpopo, to integrate hydrogen into the country’s economy.</p>



<p>It is reportedly estimated that the hydrogen valley concept could add between $4 billion to $9 billion to South Africa’s Gross Domestic Product by 2050 and create between 14,000 to 30,000 direct and indirect jobs per year.</p>



<p>Meanwhile, BMW plans to bring a small fleet of iX5 Hydrogen cars to South Africa in 2024 to gauge interest with government representatives, thought leaders and potential customers.</p>



<p>The German auto maker is due to make an announcement soon regarding an agreement with two large South African multinationals to work together to use hydrogen as an energy source.</p>



<p>Speaking to FORBES AFRICA ahead of the IAA Mobility 2023 show in Munich in September, Dr Jürgen Guldner, general program manager of hydrogen technology at the BMW Group, says the future of energy is electric.</p>



<p>“Electricity produced from solar, wind, and hydropower will be the backbone of our energy system, versus today where we produce energy from coal, gas, oil, and a little bit from the sun,” says Guldner.</p>



<p>Electricity has a few issues that can be solved with hydrogen, he explains; the main one being how difficult it is to store electricity over a long period of time. “You have to use something like hydrogen as a gas for chemical component molecules instead of electrons to store energy over longer periods of time, like several months.”</p>



<p>The feedback from BMW customers is that not all are 100% happy with a battery electric vehicle; they want to be emission-free but prefer to drive like they currently do without worrying about charging, he says.</p>



<p>“Hydrogen does exactly this; a hydrogen car is an electric car – the only difference is the energy is stored as hydrogen and not as electricity in a battery.”</p>



<p>The iX5 hydrogen prototype that FORBES AFRICA had access to briefly in Munich showcased the vehicles fitted with two 700-bar tanks that contain 6kg of hydrogen in total, which can be operated in any weather condition. The eDrive’s peak power battery can supply additional power boost on top of the electric energy from the fuel cell system.</p>



<p>The iX5 is based on the current BMW X5, has a total output of 296kW and a range of 504km without refueling the tanks. It can go from 0-100km/h in under six seconds, and has a top speed of 185km/h.</p>



<p>Hydrogen powered fuel-cell electric vehicles (FCEVs) are extremely rare, with only 15,391 units sold globally in 2022, representing 0.02% of global passenger sales when compared to the 10.5 million battery electric vehicles (BEVs) sold in 2022. In Japan alone, there was a huge drop in sales, from 2,440 vehicles sold in 2021, vs. 844 in 2022.</p>



<p>These stats were shared by BloombergNEF <em>Electric Vehicle Outlook 2023</em> report, which said figures were so low that it could not make future projections: “We are not able to make a long-term outlook for passenger FCVs while sales are so low, show limited momentum and are highly concentrated in a few markets and models.”</p>



<p>There are two mass-produced hydrogen vehicles on sale today: the Toyota Mirai and the Hyundai Nexo. Upcoming FCEV models include the BMW iX5, Honda CR-V, Hyundai Staria, Kia Carnival, and Toyota GR Yaris H2.</p>



<p>While the industry is still an experimental one, there are concerns from scientists about the lack of data on hydrogen leaks and the potential harm they could cause, according to <em>Reuters</em>, which may cause a blind spot for the nascent industry. It said at least four studies concluded that hydrogen loses its environmental edge when it seeps into the atmosphere.</p>



<p>Despite this, the European Commission’s proposed REPowerEU plan aims to produce 10 million tons (MT) of renewable hydrogen and 10MT of imported renewable hydrogen by 2030, as part of achieving climate neutrality by 2050.</p>


On Location BMW iX5 Hydrogen Antwerp

Hydrogen Cars On The Horizon In Africa


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>Paxlovid—Pfizer’s antiviral Covid-19 treatment—is 37% effective at preventing hospitalization or death in high-risk patients compared with no treatment, according to <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809779" target="_blank" rel="noreferrer noopener">a study</a> published Thursday in the <em>JAMA Network Open</em>, well below the 88% effectiveness rate Pfizer and regulators <a href="https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19" target="_blank" rel="noreferrer noopener">reported</a> in clinical trials in 2021—though it remains very effective at staving off death.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>The study found that when excluding hospitalizations and looking at death alone, the drug is 84% effective.</p>



<p>The observational study analyzed electronic health records from thousands of patients at the Cleveland Clinic Health System in 2022 and early 2023 to determine Paxlovid’s effectiveness, using real-world data rather than the clinical trials that were used before.</p>



<p>The study also found another antiviral Covid-19 treatment, Merck’s Lagevrio, was 42% effective in preventing hospitalization or death and 77% effective against death alone.</p>



<h2 class="wp-block-heading" id="h-what-we-don-t-know">WHAT WE DON’T KNOW</h2>



<p>Why the effectiveness has fallen. The study authors noted the clinical trials were conducted among unvaccinated patients who had limited natural immunity, whereas this study was conducted in a real-world population including vaccinated and previously infected patients who had some other defenses against the coronavirus. They also noted the original clinical studies were completed when the Delta variant was the most common strain of the virus while their study was conducted when the Omicron variant was, suggesting that the drug could work differently with different strains.</p>



<h2 class="wp-block-heading" id="h-news-peg">NEWS PEG</h2>



<p>While they note the effectiveness has fallen, the study’s authors still say these drugs are useful tools in fighting Covid-19, arguing both drugs can be used in nonhospitalized Covid-19 patients to prevent the most severe outcomes.</p>



<h2 class="wp-block-heading" id="h-crucial-quote">CRUCIAL QUOTE</h2>



<p>Paxlovid is still “definitely recommended for high-risk patients,” said University of North Carolina professor Danyu Lin, one of the study’s authors, according to&nbsp;<a href="https://www.bloomberg.com/news/articles/2023-09-21/paxlovid-study-shows-effectiveness-against-covid-has-declined?srnd=premium" target="_blank" rel="noreferrer noopener">Bloomberg</a>.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>Paxlovid, a course of oral pills, first&nbsp;<a href="https://www.pfizer.com/news/press-release/press-release-detail/pfizers-paxlovidtm-receives-fda-approval-adult-patients#:~:text=PAXLOVID%20has%20been%20available%20in,remain%20consistent%20with%20the%20EUA." target="_blank" rel="noreferrer noopener">became available</a>&nbsp;in December 2021 and is to be taken early in a patient’s infection. They’re designed to prevent patients who already have Covid-19 from becoming hospitalized or dying, particularly patients who are at an elevated risk of severe Covid-19 due to age or medical conditions. New information on Paxlovid’s effectiveness comes amid fears of a new wave of Covid-19 this fall. In the week ending September 9, 20,538 people were hospitalized for Covid-19, a 7.7% increase over the week prior, according to the&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths" target="_blank" rel="noreferrer noopener">Centers for Disease Control and Prevention</a>. Since the onset of the pandemic, 1.14 million people have died of the virus.</p>



<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809779" target="_blank" rel="noreferrer noopener">Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections</a>&nbsp;(JAMA Network Open)</p>



<p><a href="https://www.forbes.com/sites/brianbushard/2023/05/25/pfizers-paxlovid-covid-pill-granted-full-fda-approval/?sh=385c6c1014ec">Pfizer’s Paxlovid Covid Pill Granted Full FDA Approval</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/roberthart/2022/04/21/who-endorses-pfizers-antiviral-pill-paxlovid-for-high-risk-covid-patients-but-says-benefits-trivial-for-low-risk-groups/?sh=14dd5ff3623b">WHO Endorses Pfizer’s Antiviral Pill Paxlovid For High-Risk Covid Patients But Says Benefits ‘Trivial’ For Low-Risk Groups</a> (Forbes)</p>


Covid Drug Paxlovid Now Less Effective Than In Early Trials—But It’s Still Great At Preventing Death


<p>A new wave of innovation is rising on the African continent, where startups are leveraging AI to address local challenges, fueling sustainable growth, and forging a path for others to follow. The AI industry on the continent is expanding rapidly, with reportedly over 2,400 companies specializing in the industry as of this year.</p>



<p>Spending on AI innovation in Africa and the Middle East is likely to see the fastest growth in AI spending in the world, hitting $3 billion this year and over $6 billion by 2026 per the International Data Corporation (IDC). This innovation is both locally and internationally-driven, with organic AI-based startups across the continent, as well as collaborative initiatives such as Google’s first AI research center in Ghana, launched in 2018.</p>



<p>In the heart of Cameroon, in the capital city of Yaoundé, resides Agrix Tech — a startup committed to aiding smallscale farmers in their battle against plant diseases and pests. These threats, exacerbated by the ongoing climate crisis, pose a critical challenge to agriculture. Agrix Tech&#8217;s innovative solution is a mobile app that empowers farmers to scan their plants&#8217; leaves. Leveraging AI, the app identifies any ailments and suggests appropriate interventions.</p>



<p>What sets Agrix Tech apart is its dedication to inclusivity. The app&#8217;s features are available regardless of location or internet connectivity — crucial for remote farmers. &#8220;The app can work offline as the AI model is embedded into the mobile app,&#8221; states founder and CEO Adamou Nchange Kouotou to FORBES AFRICA. “This allows farmers with no internet connection to still use it. The app can also be set in many local African languages.&#8221; By extending its AI library to other developers, Agrix Tech is broadening the reach of its crop and disease detection capabilities.</p>



<p>In Nairobi, Kenya, is another groundbreaking company making use of AI. Since its inception in 2012, SunCulture has made significant strides in equipping farmers with precision irrigation solutions.</p>



<p>Starting with solar-powered irrigation and pay-as-you-go financing, the company has expanded its reach from Kenya to Ethiopia, Uganda, Zambia, and the Ivory Coast, among others.</p>



<p>“It’s a viable business idea,” says SunCulture CEO Samir Ibrahim.</p>



<p>Approximately 90% of smallholding farms on the continent rely on rainfall for irrigation. As a result, the timing of planting, fertilizing, and harvesting is critically dependent on weather forecasts, which are often too broad or inaccurate. SunCulture&#8217;s solution — a trailblazing amalgamation of technologies called AgOptimized — addresses this issue head-on. The app gathers local soil and weather data, integrates it with meteorological and satellite data, and analyzes it alongside historical trends using AI. The result? Detailed, localized weather forecasts and recommendations on irrigation, fertilizing, and pest control, designed to lower costs and maximize farming yields.</p>



<p>Further south in Johannesburg is an AI startup that aims to meet their bold slogan of ‘AI for Africans, By Africans, Solving African Problems’. Lelapa has crafted an AI-based language- model-as-a-service named Vulavula.</p>



<p>Linguistic diversity is the heartbeat of Africa, and nowhere is this more evident than in South Africa, a country that proudly recognizes 12 official languages. Yet, the digital space often falls short in catering to this richness. That&#8217;s where Vulavula steps in, carving out a unique niche in the landscape of AI applications.</p>



<p>“We tackle the challenges of language diversity through very careful data creation and curation with the help of sociolinguists who understand the nuances of dialects,” says Jade Abbott, Director at Lelapa AI. “Our vision is for Vulavula to be used across education, healthcare, government. </p>



<p>Children learn maths best when taught in their home language, people die because doctors do not speak the same languages as their patients, and many people can’t participate in government because majority of the resources are available in English or Afrikaans.” </p>



<p>Vulavula harnesses the power of AI to provide real-time translation and transcription services, enabling businesses to communicate with their customers in their own language seamlessly. </p>



<p>Ubenwa, a Nigerian-owned AI startup, is making significant strides in the realm of neonatal health. Named after the Igbo term for &#8216;baby&#8217;s cry&#8217;, Ubenwa has developed an AI system that deciphers infants&#8217; cries to detect early signs of neurological issues. It specifically targets birth asphyxia — one of the leading causes of infant mortality in sub-Saharan Africa — by analyzing frequency, pitch, and other key acoustic features in a baby&#8217;s cry. This AI- powered approach provides a low-cost, non-invasive diagnostic tool for early intervention, potentially saving many young lives.</p>



<p>What sets Ubenwa apart is its commitment to accessibility. Their AI solution operates independently of internet connectivity, a pivotal feature ensuring its usability in Africa&#8217;s remote areas. Bymeeting this challenge head-on, Ubenwa exemplifies how AI can be harnessed to tackle region-specific healthcare issues, paving the way for other AI startups to make impactful strides in their domains.</p>



<p>On a broader scale, Ubenwa underscores the transformative potential of AI in healthcare, particularly in settings with limited resources. Their innovative approach is a powerful testament to the potential of AI in Africa, spotlighting the profound societal impact of locally-sourced solutions to local challenges.</p>


Close-up of businesswoman use computer while use digitization display for monitoring the data in business office.

Africa’s AI-Based Businesses And Innovations


<p><strong>The tech behemoth’s latest iPhone features a new USB-C charging port and titanium frame for its higher-end models.</strong></p>



<p>Apple has unveiled the iPhone 15, with the base models 15 and 15 Plus priced at $799 and $899 respectively, in its most anticipated product event of the year. The higher-end 15 Pro and 15 Pro Max will be priced at $999 and $1,199 respectively.</p>



<p>As usual, the iPhone 15 will come equipped with a better camera and upgraded processing power, but it will also feature a significant change: a USB-C port for charging and data transfers. Apple was forced to do away with its Lightning port in iPhones after the European Union passed a law last year that requires all mobile devices to accommodate a common&nbsp;<a href="https://www.forbes.com/sites/siladityaray/2022/10/26/weve-no-choice-apple-says-iphones-will-switch-over-to-usb-c-chargers-to-comply-with-new-eu-law/?sh=786790cabcde">USB-C&nbsp;</a>charger.</p>



<p>The consumer tech giant also announced two new makes of the Apple Watch: the Apple Watch Series 9, which it said was its first carbon neutral product ever, and the Apple Watch Ultra 2. Sustainability was one of the central themes of the event, where Apple detailed its increased use of recycled materials like cobalt in the battery and energy efficient manufacturing and transportation practices to produce the Apple Watch Series 9. This comes ahead of the company’s goal to achieve carbon neutrality by 2030.</p>



<p>With inconspicuous changes in design and appearance, the screen sizes for the standard iPhone 15 models are the same as before (6.1 inch and 6.7 inch), but the iPhone 15 Pro and Pro Max have a slightly larger display as their bezels are thinner than previous iPhones, the company announced. The Pro iPhones are built with Grade 5 titanium frames for the first time rather than stainless steel, making them the lightest Pro phones Apple has ever built.</p>



<p>Similar to its predecessor, iPhone 15 has a matte finish, but the edges of the phone are more rounded than before. The regular models are available in pink, yellow, green, blue and black while the Pro models come in black, blue and white titanium. All new phones have the “Dynamic Island,” an interface that was first added to iPhone 14 Pro that lets users see notifications in the black pill-shaped notch at the top of the display.</p>



<p>Apple touted the phone’s upgraded camera capabilities: a 48-megapixel camera sensor is replacing the 12-megapixel and lets users zoom into photos while capturing minute details and nuances. The new Pro phones come with a feature that uses machine learning to detect when a person is in the photo, enabling you to automatically switch to portrait mode even after a photo has been taken.</p>



<p>If you’re on a call using the iPhone 15 Pro, a machine learning-based feature called “voice isolation” prioritizes the speaker’s voice and drowns out background voice. The phones are also enabled with an emergency SOS service and roadside assistance while off the grid.</p>



<p>The pricier models come with a performance edge, thanks to a new A17 chip. All new iPhones are embedded with a new ultrawide-band semiconductor, a technology that uses radio waves to send and receive signals, to make location tracking on the Find My app more accurate.</p>



<p>The ring/mute slide switch, which has never changed since Apple launched the original iPhone in 2007, has been replaced in iPhone 15 Pro models with an “Action Button” that can be customized to set different functionalities like starting a voice recording, launching the camera or opening the flashlight.</p>



<p>For the Apple Watch Series 9 and a second generation of the Apple Watch Ultra , the look and design for the new watches has remained consistent, but their guts have gotten an upgrade, with 30% faster processing speed and brighter screens. The two new Apple Watches are equipped with a feature that lets users double tap their index finger and thumb to carry out actions like accepting or ending a call, and playing or pausing music with just one hand.</p>



<p>Apple’s latest product reveal comes at a crucial time for the company. Demand for smartphones is&nbsp;<a href="https://www.bloomberg.com/news/newsletters/2023-08-06/apple-iphone-15-comes-amid-us-sales-slowdown-tim-cook-q3-earnings-comments-lkzfs14u" target="_blank" rel="noreferrer noopener">slowing</a>&nbsp;down across the industry, and Apple’s iPhone sales dropped about 2% year over year in the third quarter of 2023. Core to its business, iPhones, Apple Watches and AirPods accounted for about 60% of Apple’s $394.3 billion annual revenue in 2022.</p>



<p>Although more mainstream, the new iPhone and Apple Watches aren’t the only products that Apple announced this year. In June, alongside new Macs, Apple introduced the <a href="https://www.forbes.com/sites/johnpaczkowski/2023/06/07/this-is-what-its-like-to-use-apples-new-vision-pro-mixed-reality-headset/?sh=43c3323539e4">Apple Vision Pro</a> mixed-reality headset, its first major new product category since the Apple Watch made waves in 2015. The iPhone 15 lets users create photos and videos that are compatible with the Apple Vision Pro.</p>


Apple Holds Product Unveiling Event

Apple Kills Lightning In iPhone 15 And Announces Carbon Neutral Apple Watches


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>Apple and Nvidia stocks tanked for the second consecutive trading session Thursday, a rare down stretch for the Silicon Valley titans this year fueled by concerns about each of their explosive sales.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>Apple shares slipped 3.4% by 2:25 p.m. Eastern time after Bloomberg&nbsp;<a href="https://www.bloomberg.com/news/articles/2023-09-07/china-plans-to-expand-iphone-ban-to-some-state-backed-firms-in-blow-to-apple?srnd=premium" target="_blank" rel="noreferrer noopener">reported</a>&nbsp;China is considering banning iPhone usage among some government workers and employees at state-owned corporations, casting doubt on Apple’s strength in the country which accounts for roughly a fifth of its sales.</p>



<p>The slide comes a day after Apple shed 3.6% – its 6.9% dip since Tuesday marks the steepest two-day loss for the world’s most valuable company since November.</p>



<p>Nvidia shares also dropped about 3% Thursday, bringing its two-day loss to 5.5% as the S&amp;P 500’s best-performer of 2023 suffered a rare tumble.</p>



<p>The artificial intelligence leader’s stock slump came as a dubious conspiracy theory&nbsp;<a href="https://twitter.com/JesseCohenInv/status/1699307464619876691" target="_blank" rel="noreferrer noopener">proliferated&nbsp;</a>on X, the social media site formerly known as Twitter, suggesting that Nvidia has artificially inflated revenue in its AI segment by lying about its sales to CoreWeave, a Nvidia-backed cloud computing startup&nbsp;<a href="https://www.bloomberg.com/news/articles/2023-08-30/coreweave-said-to-seek-stake-sale-at-up-to-8-billion-valuation" target="_blank" rel="noreferrer noopener">reportedly</a>&nbsp;valued at about $8 billion.</p>



<p>That theory is “nonsense,” Bernstein analyst Stacy Rasgon wrote in a Thursday note to clients he “very grudgingly” sent out, encouraging investors to not get “your investment thesis from Twitter randos.”</p>



<h2 class="wp-block-heading" id="h-big-number">BIG NUMBER</h2>



<p>$250 billion. That’s how much market capitalization Apple and Nvidia shed over the last two days.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>Apple and Nvidia are two of the seven tech stocks&nbsp;<a href="https://www.forbes.com/sites/dereksaul/2023/04/10/these-7-tech-stocks-command-almost-90-of-the-sp-500s-gains-signaling-market-rally-may-not-be-so-healthy/?sh=65e0aafc65d5">accounting for</a>&nbsp;a large majority of major stock indexes’ gains this year, leading to lingering questions about the depth of the strong market (Alphabet, Amazon, Meta, Microsoft and Tesla round out the super seven). Both Apple and Nvidia set all-time high share prices this year, but on far different trajectories. Apple rode a steady 42% gain this year, just ahead with the tech-heavy Nasdaq’s 32% rise, thanks to&nbsp;<a href="https://www.forbes.com/sites/dereksaul/2023/05/04/apple-beats-quarterly-profit-sales-estimates-despite-interest-rate-headwinds/?sh=77f139f03637">solid</a>&nbsp;5% and 6% earnings beats during the first and second quarters, respectively, while Nvidia more than tripled in share price due to&nbsp;<a href="https://www.forbes.com/sites/dereksaul/2023/08/23/nvidia-earnings-stock-soars-as-ai-giant-again-smashes-quarterly-expectations/">exploding</a>&nbsp;expectations about its AI business, which grew by 141% just last quarter.</p>



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<h2 class="wp-block-heading" id="h-crucial-quote">CRUCIAL QUOTE</h2>



<p>“The Nasdaq is sinking as one bad Apple spoils a bunch of mega-cap tech stocks,”&nbsp;<a href="https://www.marketpulse.com/" target="_blank" rel="noreferrer noopener">Oanda</a>&nbsp;analyst Edward Moya wrote Thursday. The index is down 2% over the last two days, steeper than the S&amp;P 500’s 1% loss.</p>



<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://www.bloomberg.com/tosv2.html?vid=&amp;uuid=14d8c1fa-4dad-11ee-bf85-ff6800d7a7ae&amp;url=L25ld3MvYXJ0aWNsZXMvMjAyMy0wOS0wNy9jaGluYS1wbGFucy10by1leHBhbmQtaXBob25lLWJhbi10by1zb21lLXN0YXRlLWJhY2tlZC1maXJtcy1pbi1ibG93LXRvLWFwcGxlP3NybmQ9cHJlbWl1bQ==" target="_blank" rel="noreferrer noopener">BLOOMBERG<strong>Bloomberg</strong></a></p>



<p><strong></strong><a href="https://www.forbes.com/sites/dereksaul/2023/08/23/nvidia-earnings-stock-soars-as-ai-giant-again-smashes-quarterly-expectations/" target="_blank" rel="noreferrer noopener">MORE FROM FORBES<strong>Nvidia Earnings: Stock Soars As AI Giant Again Smashes Quarterly Expectations</strong><small>By&nbsp;<strong>Derek Saul</strong></small></a></p>



<p><a href="https://www.theverge.com/2023/8/8/23824661/coreweave-nvidia-debt-gpu-ai-chips-collateral" target="_blank" rel="noreferrer noopener">THE VERGE<strong>How to get your startup a loan with one easy computer part</strong></a></p>


Apple Ahead Of The IPhone 15 Launch

Apple And Nvidia’s Losses This Week Hit $250 Billion


<h2 class="wp-block-heading" id="h-topline">TOPLINE</h2>



<p>The Food and Drug Administration&nbsp;<a href="https://www.fda.gov/news-events/press-announcements/fda-takes-action-updated-mrna-covid-19-vaccines-better-protect-against-currently-circulating" target="_blank" rel="noreferrer noopener">gave its approval</a>&nbsp;for emergency use Monday to new updated Covid-19 vaccines from Pfizer-BioNTech and Moderna that are specially designed to protect against the latest dominant strain of the coronavirus, Omicron variant XBB.1.5—the latest effort of drugmakers, regulators and doctors to keep up with the virus’ ever evolving nature.</p>



<h2 class="wp-block-heading" id="h-key-facts">KEY FACTS</h2>



<p>Anyone 5 or older is eligible to receive a single booster dose of the newly updated vaccines regardless of how many shots they’ve received before, as long as it’s at least 2 months since the last dose they received of any Covid-19 vaccine, the FDA announced.</p>



<p>Children between the ages of six months and four years are eligible to receive one or two doses of the new vaccines if they’ve been vaccinated against Covid-19 before, but if they’ve never received a vaccine, they’re eligible to receive three doses of the new Pfizer-BioNTech shot or two doses of Moderna, the FDA said.</p>



<p>This comes after the new XBB lineage of coronavirus, a group of new variants that emerged in late 2022, became the most common strain.</p>



<p>After the emergence of this new lineage, the FDA encouraged Pfizer-BioNTech, Moderna and Novavax to create new vaccines specialized to defend against it.</p>



<p>These will be the first Covid-19 vaccines that aren’t free and paid for by the U.S. government, with&nbsp;<a href="https://apnews.com/article/science-health-business-covid-medicare-1a5d65356ebc7b5bc76524ae99deb55e" target="_blank" rel="noreferrer noopener">Pfizer</a>&nbsp;and&nbsp;<a href="https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-expects-price-its-covid-vaccine-about-130-us-2023-03-20/" target="_blank" rel="noreferrer noopener">Moderna</a>&nbsp;both estimating their shots will cost between $110 and $130 per dose, though many health insurances plans will cover it and the&nbsp;<a href="https://www.cdc.gov/vaccines/programs/bridge/index.html" target="_blank" rel="noreferrer noopener">CDC’s Bridge Program</a>&nbsp;will pay for some uninsured Americans’ vaccines.</p>



<h2 class="wp-block-heading" id="h-key-background">KEY BACKGROUND</h2>



<p>Drugmakers have released a number of new iterations after the first Covid-19 vaccines were administered in late 2020. In fall 2021, the first booster shots were authorized by the FDA and were meant to help replenish waning immunity to the virus months after people received their initial doses. Then, after a new variant of the virus called Omicron, which was more resistant to the original vaccines, sparked a vicious new wave of the pandemic, drugmakers released a modified “bivalent” booster shot in fall 2022. That vaccine was designed to protect against both the original virus as well as Omicron. This new booster will attempt to do what that bivalent booster did with Omicron, but with the new XBB strains.</p>



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<p>By signing up, you accept and agree to our&nbsp;<a href="https://www.forbes.com/terms-and-conditions" target="_blank" rel="noreferrer noopener">Terms of Service</a>&nbsp;(including the class action waiver and arbitration provisions), and&nbsp;<a href="https://www.forbes.com/privacy" target="_blank" rel="noreferrer noopener">Privacy Statement</a>.</p>



<h2 class="wp-block-heading" id="h-what-to-watch-for">WHAT TO WATCH FOR</h2>



<p>Now that the FDA has approved the drugs, the Centers for Disease Control and Prevention is&nbsp;<a href="https://www.federalregister.gov/documents/2023/08/25/2023-18288/advisory-committee-on-immunization-practices" target="_blank" rel="noreferrer noopener">scheduled to meet</a>&nbsp;on Tuesday to decide whether it will recommend people receive the new booster shots, an additional standard regulatory step that each of the previous iterations of the vaccines have had to complete. People won’t be able to receive the new vaccines until the CDC gives its signoff.</p>



<h2 class="wp-block-heading" id="h-surprising-fact">SURPRISING FACT</h2>



<p>While Pfizer-BioNTech and Moderna’s new vaccines were approved on Monday, the FDA still hasn’t approved Novavax’s. The company, which was a late entry into the Covid-19 vaccine market, had its&nbsp;<a href="https://www.yalemedicine.org/news/covid-19-vaccine-comparison#:~:text=Status%3A%20The%20vaccine%20was%20authorized,it%3A%20People%2012%20and%20older." target="_blank" rel="noreferrer noopener">first vaccines approved</a>&nbsp;in July 2022. Its vaccines, unlike Pfizer-BioNTech and Moderna’s do not use mRNA technology, but rather are subunit vaccines that use a piece of the virus to invigorate a body’s immune response. The company said in an email Monday its vaccines have already arrived in the U.S. and, despite not being approved alongside Pfizer-BioNTech and Moderna’s, are still awaiting FDA approval. The company reiterated that its vaccines will be widely available across the country, but “timing is ultimately at the discretion of the FDA.” By 2:45 p.m. Eastern Time, Novavax’s stock price had fallen 10% to around $8 a share. Neither Pfizer nor Moderna’s stock moved significantly. Both fell less than 1.5%.</p>



<h2 class="wp-block-heading" id="h-news-peg">NEWS PEG</h2>



<p>This comes as Covid-19 hospitalizations begin to rise across the U.S. In the week ending August 27, the most recent data available, hospital admissions for Covid-19 were up 15.7%, according to&nbsp;<a href="https://covid.cdc.gov/covid-data-tracker/#maps_new-admissions-rate-county" target="_blank" rel="noreferrer noopener">the CDC</a>. That’s 17,418 hospital admissions during that week, and while that is still a far cry from the peak in January 2022, when there were around 150,000 hospitalizations a week, doctors believe it signals that a new wave could be coming in the fall.</p>



<h2 class="wp-block-heading" id="h-tangent">TANGENT</h2>



<p>These new vaccines follow doctors’ long held predictions that Covid-19 vaccines will likely become similar to the influenza vaccine, where a new iteration is released annually to keep up with new strains of the virus. At a September 2022 White House briefing, Anthony Fauci, former director of the National Institute of Allergy and Infectious Diseases and the leader of the federal government’s response to the pandemic, said: “We likely are moving towards a path with a vaccination cadence similar to that of the annual influenza vaccine, with annual updated Covid-19 shots matched to the currently circulating strains for most of the population.”</p>



<h2 class="wp-block-heading" id="h-further-reading">FURTHER READING</h2>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2023/09/01/its-ok-to-get-your-covid-flu-and-rsv-shots-at-the-same-time-experts-say/?sh=7a857a4c3099">It’s Okay To Get Your Covid, Flu And RSV Shots At The Same Time, Experts Say</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/roberthart/2023/09/06/modernas-updated-covid-vaccine-is-effective-against-pirola-variant-as-concern-over-new-strain-grows/?sh=18b82c3a1a06">Moderna’s Updated Covid Vaccine Is Effective Against Pirola Variant—As Concern Over New Strain Grows</a>&nbsp;(Forbes)</p>



<p><a href="https://www.forbes.com/sites/ariannajohnson/2023/09/06/fda-may-approve-new-covid-boosters-by-friday-as-deaths-spike-report-says/?sh=5bc3a51b54f2">FDA May Approve New Covid Boosters By Friday As Deaths Spike, Report Says</a> (Forbes)<a href="https://www.forbes.com/sites/willskipworth/"></a></p>


Tag: Coronavirus Pandemic

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