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You Only Live Twice

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Science is pumping in billions searching for solutions that will help humans live longer – and better – and one day even indefinitely.

If you are under 50 years old and reading this article, treat it as a crystal ball – and it will tell you that chances are you may live for another 100 years.

There are species of sharks, whales and turtles that live for hundreds of years. Likewise, researchers are trying to figure out how to make you live longer, if not forever.

“If we are made from the same ‘stuff’ then what’s stopping us from achieving the same,” asks John Sanei, a futurist and entrepreneur based in Johannesburg, South Africa.

For decades, scientists have been trying to do so. But before we go to the future, we must dwell on the past, and the present.

In 1770, Africans had an average life expectancy of a mere 26 years. With newer ways to cure deadly diseases such as small pox and polio, life expectancy gradually increased. Exactly two centuries later, Africans were living to almost 47 years. In 2001, the average life expectancy of Africans rose to 51 years, in 2005 to 53 years, in 2010 to 57 years and in 2015 to 60 years.

Even with such numbers, Africans are still dying sooner than most people in First World countries where life expectancy is in the 80s.

Dr Susan Coetzer spent 14 years studying to be a geriatrician, a specialty focusing on healthcare of the elderly, at the Wits University Donald Gordon Medical Centre in Johannesburg in South Africa. She says the costs and access to healthcare are the biggest barriers. In Africa, according to Coetzer, poverty and lower education levels link to both frailty and cognitive diseases lowering life expectancy.

“Other risks are because of lifestyle-related problems like diabetes, hypertension and obesity. The HIV epidemic has also decreased life expectancy in the past, but with the availability of treatment, this has improved and we will certainly see more HIV-infected older people in the future,” she says.

As the universe often works, what has an advantage also has a disadvantage. Old age often comes with various accompanying diseases that require constant supervision and medication. The more old people Africa has, the more money it needs to pay for their upkeep.

“Older patients are at a higher risk of becoming frail and frail patients have been proven to cost more – in terms of hospitalization, medication and other needs and of course, the additional care. Even most of the developed countries are battling to budget for the increased financial impact,” says Coetzer.

It is true. In October last year, South Africa had 17.5 million social grant recipients and 3.7 million of them were the aged. There are also few specialists to give proper care to the elderly.

“There are less than 20 geriatric specialists in South Africa serving a population of more than seven million people older than 60 years,” says Coetzer.

The good news is we are in an era where scientists are developing the technology to prevent aging and the diseases associated with it.

If they succeed, you could work and live long without experiencing most symptoms of old age.

For this, it will take an understanding of our genes and aging itself.

According to Dr Samantha Baron, a research and development scientist at Optiphi Skin Care in South Africa who is an expert in genetics and deoxyribonucleic acid (DNA), the primary cause of aging is damage to structures within the cells.

“Damage within the cell can be induced by oxidative stress, glycation, telomere shortening, mutations and epigenetic contributions. The progression of this damage is what leads to eventual cell death and what we know as the general cause of aging,” she says.

It means every time you celebrate your birthday, the probability of death increases. The older you get the more you become prone to diseases like Alzheimer’s, cancer, diabetes, heart disease and arthritis — all associated with age.

Dr Aubrey de Grey, a biomedical gerontologist, and co-founder of the Strategies for Engineered Negligible Senescence (SENS) Research Foundation tells FORBES AFRICA these can be avoided. Instead of solving death, he looks at extending life.

Dr Aubrey De Grey. Photo supplied.

“Aging can absolutely not be ‘cured’ but it absolutely can, although not yet, of course, be eliminated by medical interventions that are not cures…

“We already feel comfortable with spending lots of money trying to make Alzheimer’s history, so if we stop pretending that it is somehow separate from ‘aging itself’, we will have taken a huge step towards wanting to make that history too,” he says.

READ MORE: From Death Comes Life

De Grey believes we can increase our lifespan by periodic, comprehensive repair and maintenance of the human body.

“We want to restore the molecular and cellular structure and composition of the body to something like how it is in early adulthood. That means things like using stem cells to replace cells that the body does not naturally replace on its own by cell division when they die, or introducing new enzymes to break down waste products that the body does not naturally break down,” he says.

Baron agrees. She says if scientists could delay cell death by reprogramming cells, increasing cellular lifespan and increasing the efficiency in damage repair mechanisms, they could potentially prevent the onset of diseases associated with aging.

“If true cellular regeneration can be accomplished, then these diseases can be treated and the damage reversed.”

Humans are already able to manipulate the longevity of organisms.

A number of researchers in the United States (US) identified a drug that delays several age-related symptoms in mice. It has sparked massive debate and research in the world of science.

“With an experiment that replicated stem cell-like conditions, Salk Institute researchers made human skin cells in a dish look and behave young again, and mice with premature aging disease were rejuvenated with a 30% increase in lifespan. The Salk Institute expects to see this work in human trials in less than 10 years,” says Sanei.

A growing interest in this field also led to biologists at Osaka University in Japan to discover a new way to nurture and grow the tissues that make up the human eyeball. Using a small sample of adult skin, they are able to grow retinas, corneas and the eye’s lens.

Another team of researchers in the US injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.

Longevity Escape Velocity

According to Sanei, in the next 10 to 12 years, we will hit ‘longevity escape velocity’ — the point at which, for every year that you’re alive, science is able to extend your life for more than a year.

According to Oliver Medvedik, a Director at the Maurice Kanbar Center for Biomedical Research and VP of the longevity-focused non-profit Lifespan.io, interventions are being developed that “reprogram” the chemical signature of the genome, referred to as the epigenome, to a more youthful state.

“The epigenome is largely responsible for determining what the status of each of your cells is. As an adult, you typically don’t want this status to change, but as we age, it does change for the worse,” he tells FORBES AFRICA.

There is also a new class of drugs being developed known as ‘senolytics’ that specifically target and destroy cells that are too far gone and are causing secondary damage in the body. These aged cells are referred to as ‘senescent’.

“Tremendous progress has also been made in learning exactly how to reprogram the epigenome of cells so that they become new adult stem cells. These can then be reintroduced into the body to potentially promote the rejuvenation of tissues and organs, after perhaps senescent cells have been cleared,” says Medvedik.

The low-hanging fruits are small molecules that may help slow down aspects of the aging process and allow us to live healthier and longer.

“One such candidate molecule has been known for many years as a Type 2 diabetes treatment, metformin, and is now being set for clinical trials,” says Medvedik.

Scientists are also debating how long humans can possibly live in the future. Some say we will live up to 150, others say 200, and some go as far as a 1,000 years.

Baron says that at this point in time, this is mere speculation.

“It is too premature to accept a maximum lifespan of humans. Eventually, science may lead to the first 200-year-old. I would have to say that living to a 1,000 years old is highly improbable.”

Similar to De Grey and Medvedik, she says to increase lifespan, research needs to focus on improving DNA repair mechanisms, making it more efficient. This would slow down the progression of accumulated damage within the cells and consequently aging. The cells will be able to maintain homeostasis for longer.

Alternatively, she suggests the focus to be on reversing the signs of damage through cell regeneration where the healthy and younger state of the cell is obtained.

“Presently, all we can do is try to minimize the damage we provoke on to our cells by controlling our environmental factors (i.e. eat healthy, exercise, don’t smoke etc) as well as understanding our genetic predispositions. For example, at Optiphi, we offer a comprehensive DNA skin test to decipher your genetic predispositions to certain aging characteristics. Results from this test allow one to approach skin aging from a holistic point of view,” she says.

According to Baron, from an aesthetic point of view, the future market will benefit more from cell regeneration through reprogramming.

“This way you reprogram your own cells to their younger state and maintain the youthfulness of your skin. From a medical stand-point, regeneration of whole organs is definitely the future of regenerative science and exciting advances are happening in this field,” she says.

And indeed, success will mean high profits for those who invest.

Investing in the immortality industry

The rich and famous are ploughing billions into research as they try to solve the issues of ‘growing old’.

“The main wealthy people investing in this space are the techno-visionaries like Peter Thiel, Vitalik Buterin and Michael Greve but increasingly there are also people like Jim Mellon whose expertise is not in tech investing. The field is growing fast,” says De Grey.

Those with money are really keen on this next new frontier.

According to Bay Area News, Scott Smith, founder and CEO of the San Francisco-based investment bank, Viant Capital, said “the Venture Capital community has finally woken up to the fact that, next to millennials, this is the largest market in the world and it’s grossly underserved”.

The last 24 months has seen a huge uptick from the investment community.

Google’s Calico, founded in 2013, has more than $2.5 billion in funding. It paved the way for other startups and foundations like Apollo Ventures, Oisin Biotechnologies, Longevity Fund, Kizoo Technology Ventures, Methuselah Fund and Jim Mellon’s Juvenescence.

If investments trickling in are anything to go by, there is a lot of money to be made in the industry. For example, UNITY Biotechnology reported cash and investments of $198 million as of June 30 compared to $92.2 million in December.

“The increase in cash reflects net proceeds of $59.9 million from UNITY’s Series C convertible preferred stock financing, and $75.9 million from UNITY’s initial public offering. We ended this quarter in a strong financial position as a result of our recent financings. We are well-resourced to move towards our goal of extending human healthspan,” says Keith Leonard, the Chairman and CEO of UNITY in a press statement.

The company is already in first-stage human trials.

“We treated the first patient in our Phase 1 clinical trial evaluating UBX0101 in moderate to severe osteoarthritis of the knee. This is an important step in assessing the role that eliminating senescent cells may play in the treatment of diseases of aging such as osteoarthritis, and we expect to share initial results in the first quarter of next year,” says Leonard.

Big business realizes there is need for startups working in this space.

Ichor Therapeutics, a biotechnology company in New York that develops therapeutic interventions for age-associated diseases, is one of them. It has created Grapeseed.Bio, a life science strategic fund and accelerator program where life science entrepreneurs receive up to $100,000 in seed funding, technical training, full access to Ichor’s research laboratory and mentorship in exchange for equity.

“Direct funding vehicles like Grants for Growth and the TC Growth Fund, combined with mentors and a physical facility at the Tech Garden, have cultivated many promising companies in the software and tech sectors. We want to do the same in the life sciences,” says Kelsey Moody, CEO at Ichor Therapeutics and Managing Partner of Grapeseed.Bio.

The $331 billion anti-aging market

In South Africa, Mic Mann, a futurist, through his advertising and marketing agency Mann Made, co-organizes the SingularityU South Africa Summit. This year, in October, the summit is bringing to Johannesburg speakers like De Grey from all over the world to also discuss aging, longevity and a “future-proof Africa” to make sure we embrace this wave of technology coming our way.

Tickets for the whole two-day event cost between R14,850 ($1,012) and R18,150 ($1,239) and he says they are almost sold out. That’s steep prices for a country where there are more people on social grants than are employed.

“There is massive interest. We have about 100 tickets left. We are going for 1,800 people this year. Last year, we sold out at 1,300 people,” says Mann.

According to Mann, there are many investors getting into the immortality industry.

“I think there will always be a debate or drive of humanity on how we will solve the issue. Firstly, we will become amortal [pursuing a lifestyle that defies the process of aging], but we could still fall off a car or train and die. Eventually, we will become immortal and able to put our conscience in another being or hard drive,” he says.

According to the global anti-aging market research report by Orbis Research, a leading market research company, the anti-aging market is expected to reach $331.41 billion by 2021.

“The industry is exploding in size. I have seen a 1,000 percent increase in the last 18 months in investment in life extension research and technology. Everybody realizes that if life extension can fulfil its promise, many new billionaires will be made,” says Sanei.

According to Sanei, the worldwide pharmaceutical market surpassed $1.1 trillion in 2016. In 2018, the top 10 pharmaceutical companies alone are projected to generate over $355 billion in revenue.

The problem is, according to Sanei, it currently costs more than $2.5 billion, sometimes up to $12 billion, and takes over 10 years to bring a new drug to market.

John Sanei. Photo supplied.

“Nine out of 10 drugs entering phase one clinical trials will never reach patients. As the population ages, we don’t have time to rely on this slow costly production rate. Some 12 percent of the world population will be 65 or older by 2030, and diseases of aging like Alzheimer’s will pose increasingly greater challenges to society,” he says.

Although there are billions being poured into the longevity economy, many ventures have not made money.

“Very little revenue was made in the last few years…However, most life extension and longevity companies are not trying to get quick products to the market. They are searching for the holy grail of medicine: a pill or a therapy to overcome aging. This product, if successful, could generate hundreds of billions of dollars. A few billion people may end up using it eventually,” says Zoltan Istvan, a politician and former journalist who narrowly escaped death and is now trying to prove we can live longer.

While working as a journalist in Vietnam for the National Geographic channel, he almost stepped on a landmine in the jungle. It was such a nerve-racking experience he dedicated the rest of his life to overcoming death.

“It’s hard to pin down what the industry is actually worth, since so many new medicines and robotic parts are not for sale yet and are in development. But I would venture to say that some of the life extension founders and CEOs may eventually become some of the first trillionaires on the planet. If they are successful, they will be able to sell their products to virtually every person on the planet, since almost everybody wants to live longer,” Istvan tells FORBES AFRICA.

According to him, there are only a few reliable medical regenerative products on the market today.

“A few pills are coming in the one-two year pipelines that are FDA-approved and will help people live longer. But there’s an expectation that within five to seven years, an enormous amount of products will hit the market. The problem is which products are ‘snake oil’ products that aren’t FDA approved, and which are really useful for making people live longer. This will take a discerning consumer to know the difference,” he says.

Istvan loves life. His father died last year due to old age.

“Some life extensionists are afraid of death. Not me. I just love life, and since I don’t believe in an afterlife, it’s imperative I make the life I have here on earth last as long as possible — hopefully forever. Death is terrible. It’s forever. I’m haunted by it. I’m not afraid of death, but I’m haunted by my life disappearing forever — of there being no more existence of me,” he says. Istvan predicts we will gain a free year for every year we live past 2020.

“That is how fast the technology of anti-aging is developing. But at some point of this J-curve chart of life extension and living longer, humans hit a point — probably in 25 years or so — when technology and radical science simply overcome all our biological issues, and then we will live indefinitely or at least hundreds of years.”

He says hospitals may have to shut their doors.

“Medical care will go the way of the dinosaurs. At some point in the next 25 years, humans will have such good medicine and science, that pharma companies, hospitals, and doctors will begin to realize they are no longer needed. It won’t happen overnight, but by the end of this century, there will be 90% less hospitals,” he says.

It would mean life extension would have arrived. Right now, we think of medicine in terms of managing disease and how old we are. But in the future, according to Istvan, we will think in terms of getting rid of all disease and physical discomfort forever.

De Grey disagrees.

He says the only difference from the hospitals now will be that most of what hospitals will give you will be preventative.

“All it will shift is the way we think about that fictitious concept that we currently call ‘aging’ itself. We will understand that there is no such thing …,” says De Grey.

What about Africa’s existing problems?

Three generations of Black women smiling

Some argue that in Africa, however, private healthcare is expensive and government hospitals are struggling to treat people, let alone fund aging research.

De Grey, however, says there is still far too much early-life mortality in Africa, more than in the rest of the world – but as of 2015, not a single country in the whole world, including Africa, had a life-expectancy below 50.

“Therefore, Africa is catching up, which, of course, means that it is on course to have the same age-related health crisis that the industrialized world already has. Thus, it is highly timely that African nations should start to pull their weight in this space.”

READ MORE: Investment Marketplace Coming To Africa

Baron says should the lifespan of people increase, we will have bigger problems such as the ever-increasing population, further decline in food and water sources, and large economic transformations that will need to happen.

“[These] problems are already of major concern today and should be addressed before we consider further burdening our already limited resources,” she says.

Istvan sees it another way.

He says if people think they will live hundreds of years, they may not have children or even get married in the first 100 years of their lives.

“This of course will help with the overpopulation issue, and have significant structural ramification for society and human culture.”

There is another challenge. Life extension is most likely to broaden inequality. We may have a world where the super-rich can cheat death while the poor continue to die.

Zoltan Istvan. Photo supplied.

“The problem, of course, is that only the rich Africans will benefit at first. And this will be a hard fact to swallow for those people that live in poverty in Africa,” says Istvan.

De Grey however argues that such treatments will be for free.

“Keeping people healthy pays for itself so spectacularly fast that it would be economically suicidal for any country not to make the necessary investment to ensure that access is not limited by ability to pay. Today’s high-tech medicine for the elderly is not an informative precedent at all, because it doesn’t work – it doesn’t keep people healthy,” he says.

Istvan however further argues that it’s unlikely that a single pill will make people immortal. He says it’s likely to come in a combination of treatments and bionic organ replacements.

“It’s likely to take years of genetic treatments, shots or IV drugs, and organ replacement surgeries. At first, when this starts happening in 10 or 20 years, it will probably cost hundreds of thousands of US dollars, if not millions,” he says.

Longevity would mean a world where the global economy will surge, as people will be able to work much longer and stay younger much longer. Permanent retirement may be a thing of the past and people may be able to do multiple careers over hundreds of years.

 

Longevity’s impact on savings

Currently people retire at about 60 years old. If people continue to live far longer, this will be at the peak of their earning capability.

If you live into your 100s and are as strong as you were in your 30s or 40s, you will still be a part of the working population.

“Extending the human lifespan by 30 years and postponing the current retirement age would generate a massive global GDP boost,” predicts Sanei.

Currently, people retire at about 60 years old. If people continue to live far longer, this will be at the peak of their earning capability.

According to Alexander Forbes, a financial services group headquartered in Sandton, the richest square mile in Africa, retirement savings in South Africa currently amount to R4.4 trillion ($300 billion).

“[It’s] an accumulation of assets that could only have been reached because of policymakers’ insistence that if an employer does offer a retirement fund (or funds) to employees, it is mandatory for all employees to participate in the fund,” it says in its Benefits Barometer report in 2017.

This number is expected to grow as people continue to live longer. South Africa has 4.4 million people over 60 and 2.9 million over 65. According to the report, by 2050, the total population over 60 is projected to be over 6.4 million.

Sanlam, a financial services group based in South Africa, says longevity is a blessing and burden. For its centenary celebrations, the group is focusing on answering longevity questions. Through its advert, the company uses a 10-year-old ambassador to ask questions like, ‘if the person who will live to 200 has already been born, would they stay younger for longer or get older later? How long will they study for? At what age will they retire? How many jobs will they have? Will they choose the same partner for life? How many kids will they have? Will anything come with a lifetime guarantee? How would you plan for a financial future?’

“As a future thinking organization, we wanted to look into the future. We believe in long-term planning. Already, South Africans can’t retire comfortably. Only 6% South Africans retire comfortably so we had to make sure people think about the future,” says Sanlam’s marketing chief, Mariska Oosthuizen, to FORBES AFRICA.

Mikel Moyo, co-founder of Mphato & Associates, a tax consultancy firm in South Africa, says traditional financial planning speaks to retiring at age 65. Living longer means longer working lives.

“It’s is a scary thought,” says Moyo.

“Try speaking to a 30-year-old about retirement planning. The typical response is ‘65 years is 35 years away, why do I need to save now’. What people do not understand is they only have 12 pay cheques per year. This means they only have 12 opportunities to live the life they want to live, to pay for all their obligations and save for retirement. They do not have that perspective. So the rational prediction is that if people currently think 30 years after retirement is long, what happens when it’s an extra 100 years?” According to Moyo, we don’t communicate well about finances as Africans.

“We need to be able to talk about money and speak out against every bad behavior if we are to survive. If we are to live longer, we have to understand ourselves.”

Anne Cabot-Alletzhauser, Head of the Research Institute at Alexander Forbes, says longevity means the financial industry has to break away from the notion that you have to retire at a certain age.

“One of the biggest mistakes we have made in South Africa is that we would retire people at the age of 60 or 62 to make way for youth to rise up to senior positions much faster. But in fact, research shows you that you will get better productivity by having people with more experience…You can get transformation without retiring people with experience,” she says.

According to the Alexander Forbes report, there has been a rise in the number of elderly who are bread winners. Between 1996 and 2011, this number increased from 1.7 million to about 2.9 million households.

“Elderly people also appear to be continuing to work later in life. This could be because of economic pressure to continue generating an income, or it may be a reflection of a global trend: educated individuals are beginning to see that they still have value to offer professionally, even if they have hit some arbitrary cut-off date.”

She adds that people make assumptions that as you get older, you become an economic burden to the country.

“We need to change our attitude towards healthcare because the healthcare you give to someone past the age of 60 is completely different to the one you give to someone younger…If you get it right, you significantly reduce the cost of healthcare which is one of the biggest fears of what is going to happen if longevity increases.”

She says the biggest challenge for financial planning is post retirement because you have no idea of what is going to happen to your health.

According to her, quality-care of the elderly exists in the communities, not retirement homes.

“We have had a nice situation whereby adults take care of their children and the children grow up and take care of the elderly,” she says.

The problem is, according to Cabot-Alletzhauser, the financial services industry uses first-world solutions to try solving third-world problems.

“I have a real problem with the financial services industry. It is touted to be first-world quality, and indeed it is, but it solves first-world problems…The insights it has applies maybe to the top 5% of the population.”

She says retirement savings is not a priority for South Africans.

“Most South Africans work, take their income home and take care of their siblings and even grandparents. That’s our modern reality…We don’t have a stable middle class in South Africa. People enter the middle class by virtue of what their income is but they don’t stay there because they immediately get into credit problems…We aren’t focusing on how we create stability during the journey and jumped to retirement,” she says.

Instead of saving for retirement, Cabot-Alletzhauser, says she would support investing in property.

“If they have a house, when they retire, they can rent some of the rooms and make an income…There is a mistaken notion that you are going to retire at 60 and then live to 120. People will keep working if they are to live to 120. I am 69 and I am still capable of working and will continue working.”

 

Preserving and reviving dead people?

Finland-based entrepreneur Filip Poutintsev first heard about the concept of aging when he was three years old.

“I was playing with my grandfather and suddenly asked him ‘why are you so old?’. His reply was very straight forward: ‘we all get old’. After hearing that, I started crying hysterically, as at that point I realized for the first time that I too will get old,” he tells FORBES AFRICA.

At about age 12, his teacher told him about cryonics – deep-freezing the bodies of people who have just died, in the hope that scientific advances may allow them to be revived in the future.

“For me, that was like a light at the end of the tunnel. There was finally hope that I may not have to die.”

His curiosity about life and aging grew. He decided he wanted to be frozen after death but was appalled by the limited research in the industry. It compelled him to actively engage.

“I remember reading a few years ago an article about immortality that stated that if we spent as much money on life extension research as we spend on whitening our teeth, we would already be immortal. This was kind of a wakeup call for me. I realized deep inside that if I do nothing and just wait I might not make it to the time biological immortality is possible,” he says.

He founded the Immortality Foundation, which tries to create visibility and attention for anti-aging, longevity and life extension research.

“You see aging is a physical process, and the aging of humans is not different than the aging of a car, it’s just more difficult to fix.”

Breakthrough doesn’t mean everyone with access will live long. Poutintsev says once we eliminate death caused by aging and age-related diseases such as cancer, the biggest cause of death will be accidents, as our bodies will still be vulnerable to physical damage.

“If you want to live to 1,000 years, you need to be very careful not to die in traffic accidents for example. Actually, if we look at modern day statistics on death, we can calculate that even if we will become biologically immortal, our chance to live for 1,000 years is only 60%, due to all sorts of accidents,” he says.

The study of cryonics is growing rapidly.

“The process of cryopreservation involves cooling a legally-dead person to liquid nitrogen temperature where all physical decay essentially stops – with the goal of preserving tissues, organs and especially the brain with its associated memories and personality as perfectly as possible,” says the Cryonics Institute on its website.

A person held in this state is called a cryopreserved patient.

“We do not consider the legal definition of ‘death’ as a permanently irreversible state. We believe that the incredible advances being made today in biology, medicine, computers, nanotechnology and much more, inevitably point to a future where advanced science will be able to revive these patients and restore them to health and even renewed youth.”

There are more than hundreds of cryopreserved patients across the world, says the institute. And it’s costly.

A minimum whole-body suspension costs $28,000 at the Cryonics Institute. Other companies charge more.

For example, the same procedure reportedly costs $200,000 at Alcor4, $155,000 at the American Cryonics Society, $36,000 at KrioRus and $150,000 at Trans Time.

Just as vaccines, surgeries, sterilization and antibiotics ushered in a new age of longevity, new technologies like robotics will expand it further.

“Humans are slowly becoming cyborgs with artificial hips, dentures, and soon will replace all their organs with better performing bionic ones. So it’s quite possible that overpopulation won’t really affect the world, as humans will be machines, and can do things like interplanetary travel as well as only use sunlight to run their bodies, and not food or water or oxygen,” says the futurist Istvan.

There is also an impact for the geriatrics industry.

“I hope that in geriatrics, we will still maintain the ‘human’ part of interacting with patients, instead of everyone just ‘plugging in’ like a robot, says Coetzer.

Sanei agrees. He says most people he speaks to say they never want to become a cyborg but we will naturally become robot-like.

“Let’s go back to the beginning when humans developed the earliest technologies – fire and stone tools. These tools gave people new capabilities, and became extensions of our physical bodies. As we move into the future, we are not even going to notice becoming part-machine, because it’s going to be a sensible thing to do at each point in the journey,” says Sanei.

Entrepreneurship opportunities

Tech billionaires like Google co-founder Sergey Brin are already working on combating aging in the longevity labs of the west. African entrepreneurs have begun to see the merit of such research. One of them is 41-year-old Dr Danny Meyersfeld.

“I love research and being in the lab but there comes a point where you need a clean break from academia otherwise you will be there for the rest of your life,” he says.

We meet him at his offices in Illovo in Sandton. He has invited us to see the DNA-testing in his lab. Meyersfeld is the founder of DNAlysis Biotechnology.

Here, his team conducts different tests – for weight management, disease management, sports performance, skin health, skin-aging and cognitive health.

Dressed in blue jeans and a white shirt, he tells us how he started the business in 2008.

“I had a PhD in Molecular Biology and I didn’t know what to do with it…At the time, we wanted to bring biotech advancement to the South African healthcare environment and to bridge the knowledge gap that exists between academia and the consumer. There is a wealth of knowledge and research that sits in publications and academia that never gets to the people. If research is not done to make a difference to the average human, then what’s the point,” says Meyersfeld.

His idea wasn’t easy to sell.

Danny Meyersfeld. Photo by Motlabana Monnakgotla.

“For the South African market, I think we were about five years too early for these types of tests. We were this lone voice trying to sell a product but also trying to educate and create a market for something that hadn’t existed before,” he says.

The advantage was having examples from the US and European market.  They were able to learn from the mistakes of those companies to find the right model.

“But the challenge was still a lack of awareness of these types of technologies especially with healthcare practitioners because that’s where our market was. We didn’t want to go straight to the consumer; we wanted to work with dieticians and doctors so genetics can be a daily part of their work.”

According to Meyersfeld, longevity is possible but it’s more about being healthy and understanding your DNA.

“I would rather live to 90 and maintain my health than live to 120 and suffer for the last 20 years,” he says.

 

Anti-aging in the beauty business

Dr Reza Mia is the Chief Operating Officer at Anti-Aging Art, a medical aesthetic and wellness center focusing on minimally invasive anti-aging and cosmetic treatments.

“People kept coming to me and saying, ‘aren’t you a doctor, don’t you do botox, don’t you do fillers and I went and did the courses to satisfy that need. Slowly, they kept coming and bringing their brothers, sisters, friends until it became a full-time job,” says Mia.

According to Mia, the industry is growing.

“In South Africa, because it started a bit late, it’s growing faster than the rest of the world. We are normally fully-booked but we try to add doctors to take care of that demand.”

The company says it serves 500 to 600 clients every month. They are 60% women and 40% men, ranging from teenagers to people over 80. Patients pay R3,000 ($205) on average per visit.

“Mostly, people want to fix tiny problems like frown lines and sagging faces. A lot of the time, it’s small things that make them self-conscious, like sweating too much on the face and underarms. Sometimes, they just want maintenance work all over the body,” says Mia.

She says one of the challenges is a lack of the right regulations.

“We see a lot of practices opening up not owned by doctors and they obviously don’t know about the ethics…It’s hurting the industry because people are seeing other people looking unnatural and they think that’s what fillers do.”

Mia wants to expand the business, through franchising, to Tanzania and Dubai in the near future.

The quest for immortality may be very much in the future, but these futurists, doctors and scientists believe that with technology, we are irresistibly closer to finding a cure for aging than we have ever been before.

Never say die.

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Forbes Africa | 8 Years And Growing

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As FORBES AFRICA celebrates eight years of showcasing African entrepreneurship, we look back on our stellar collection of cover stars, ranging from billionaires to space explorers to industrialists, self-made multi-millionaire businessmen and social entrepreneurs working for Africa. They tell us what they are doing now, how their businesses have grown, and where the continent is headed. 

Since its inception in 2011, and despite the changing trends in the publishing industry, FORBES AFRICA has managed to stay relevant, insightful and sought-after, unpacking compelling stories of innovation and entrepreneurship on the youngest continent, in which 60% of the population is aged under 25 years.

 Many of those innovations have been solutions-driven as young entrepreneurs across the continent seek to answer questions that have burdened their communities.

 Always on the pulse, FORBES AFRICA has chronicled and celebrated those innovations – prompting the rest of the globe to pay attention and be fully engaged.

 A prime example of this is the annual 30 Under 30 list, which showcases entrepreneurs and trailblazers under the age of 30 from business, technology, creatives and sports. In 2019, we had 120 entrepreneurs on the list, finalized after a rigorous vetting and due diligence process to well laid down criteria.

 We have always maintained the highest standards of integrity in all our reporting.

 As we transition into the next milestone, FORBES AFRICA reflects on the words of civil rights activist Benjamin Elijah Mays, who once said: “The tragedy of life is not found in failure but complacency. Not in you doing too much, but doing too little. Not in you living above your means, but below your capacity. It’s not failure but aiming too low, that is life’s greatest tragedy.”

 With the transformation in the media landscape, the recent awards given to the magazine for the work done by a hard-working, determined and youthful team, serve as a reminder that we are doing something right.

 Early this year, FORBES AFRICA journalist Karen Mwendera received a Sanlam award for financial journalism as the first runner-up in the ‘African Growth Story’ category. In January, FORBES AFRICA’s Managing Editor, Renuka Methil, received the ‘World Woman Super Achiever Award’ from the Global HRD Congress.

 In reflecting on the last eight years, this edition revisits a few of the strong, resilient men and women who have graced our covers.

For some, fortunes have literally changed, as witnessed in the fall of gargantuan African empires such as Steinhoff. Of course, there have been massive moments of triumph too, which have seen some new names feature on the annual African Billionaires List. There have also been moments of tragedy with former cover stars passing away.

 Africa is ripe for the taking and is seen as the next economic frontier. The unique position the continent finds itself in will no doubt give FORBES AFRICA plenty to report on. Here’s to more deadlines and debates for the next eight years.

– Unathi Shologu

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Mastercard: Diligent About Digital In Africa

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Mastercard knows only too well that technology can drive inclusive financial growth with simpler and more efficient ways to do business and life. And Raghu Malhotra, the man spearheading this trajectory in Africa, is also focused on social progress.


In many ways, Raghu Malhotra is like the brand he works for, leaving his footprints in different parts of the world, and in some cases, the most unlikely corners.

On a scorching summer’s day in June 2016, Malhotra traveled 100km east of Jordan’s capital city Amman, to a camp with white tents named Azraq built for the refugees of the Syrian Civil War.

In the desert terrain and hot, windy conditions, people had to queue for hours on end for plates of food handed out of visiting trucks. But some of them, displaced and homeless overnight, expressed their gratitude to Malhotra, President for Mastercard in the Middle East and Africa (MEA).

Mastercard, a technology company that engages in the global payments industry, had distributed e-cards, as part of a global collaboration with the World Food Programme, to the refugees that they could now use to purchase food and other supplies from local shops.

READ MORE | The Big Bank Theory: South Africa’s Banks Of The Future

 “I spoke to the people myself and saw what their lives were… Even those who were doctors with their families and were displaced… They said to me ‘you have restored dignity to our lives; you have no idea how demeaning it is to queue up to be given food’… We actually digitized how that subsidy for food was given. Some of these things go beyond economics,” says Malhotra. 

Beyond economics.

That very simply sums up Malhotra’s mandate for Africa as well.

The New York-headquartered Mastercard, ranked No. 43 on Forbes’ list of the World’s Most Valuable Brands, with a market cap of $247 billion, which connects consumers, financial institutions, merchants, governments and business, is fostering key partnerships across the African continent to help drive inclusive economic growth.

The idea, Malhotra says, “is to get our global skill-set to operate in its most efficient form in every local economy, at the same time, we must do good, and it must be sustainable.”

He calls Africa the next bastion of growth for various industries.

“As a company, we have stated we are going to get 500 million new consumers globally. And Africa plays a big part of that whole story… We want to be an integral part of various economies here,” says the man responsible for driving Mastercard’s global strategy across 69 markets.

Raghu Malhotra President for Mastercard in the Middle East and Africa. Picture: Motlabana Monnakgotla

“It probably took us over 20 years to get the first 50 million new consumers, in my part of the world, which is the Middle East and Africa (MEA). It took us probably five years to get the next 50 million, and last year alone, we put over 50 million consumers [in the formal economy] in MEA. That is part of our whole African story, so this is just not rhetoric; we are actually building our business on that basis.”

Home to four of the world’s top five fastest-growing economies, Africa has the fastest urbanization rate in the world, the youngest population, and a rapidly expanding middle class predicted to increase business and consumer spending.

It’s a continent of opportunity for global players like Mastercard with an eye on the potential of a booming consumer base and small and medium entrepreneurs, most of whom are still not a part of the formal economy. A large proportion of Africa is still unbanked. There is enough business opportunity in offering people digital tools so they can lead respectable financial lives.

READ MORE | The Monk Of Business: Ylias Akbaraly Talks About Secret To Success And Plans To Take Africa With Him

But it is in knowing that financial inclusion is not just about technology, but more about solving bigger problems, as the World Bank says in its overview for Africa: “Achieving higher inclusive growth and reaping the benefits of a demographic dividend will require going beyond a business as usual approach to development for Africa. Going forward, it is imperative that the region undertakes the following four actions, concurrently: invest more and better in its people; leapfrog into the 21st century digital and high-tech economy; harness private finance and know-how to fill the infrastructure gap; and build resilience to fragility and conflict and climate change.”

And in order to enable financial access, Mastercard has a balanced strategy in place, with the right partnerships for inclusive growth on the continent, Malhotra tells FORBES AFRICA.

“Every emerging market has different segments of people and you need to get the right product for the right segment. What we do is a balanced growth strategy across the continent based on timing, opportunity etc… Of course, because the bottom of the pyramid is much bigger, I think what we need is to adapt things differently; that is where the inclusive growth story comes from. That is where the opportunity is, but there is a second part to it…” And that, he summarizes, is advancing sustainable growth, doing good and bringing more transparency and efficiency.

The new pragmatic dispensation of governments in Africa towards ideas, technology and innovation has surely helped open up the stage to newer segment-driven products, especially as Africa already has such global laurels as Safaricom’s mobile money transfer and micro-financing service M-Pesa that took financial access to a whole new level. Also, sub-Saharan Africa remains one of the fastest-growing mobile markets in the world.

READ MORE | Feisty And Fearless Pioneers Thandi Ndlovu & Nonkululeko Gobodo

Malhotra says he finds African governments consistent in how they are rolling out their digital vision, and in trying to collaborate towards creating better ecosystems for their economies, though each is unique with its own dossier of problems.

“When I speak to various governments around Africa, I see a commonality of what their needs are and I also see a commonality in how they are trying to respond. So I think a lot of them realize running cash economies is a very inefficient way of doing things… Also, the consumer base is much more open to new technology because there is no bedded infrastructure or legacy infrastructure. I think where governments need to start thinking a bit more is how much do they want to do completely on their own.”

Part of this transformation on the path to financial progress is alleviating the burden of cash. Cash still accounts for most consumer payments in Africa. Mastercard, which started out as synonymous with credit cards, continues its efforts to convert consumers from cash to electronic transactions, and move beyond plastic.

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Pioneer For Women In Construction Thandi Ndlovu has died

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The cover of the August (Women’s Month) edition of Forbes Africa beautifully captures the essence of the woman I interviewed only a few weeks ago. Gracious, soft-spoken, brimming with life and energy. Dr Thandi Ndlovu impressed the entire Forbes crew on that afternoon cover shoot with her broad smile, and open yet powerful demeanor.

It is with great sadness that Forbes Africa heard of the accident that took her life on Saturday the 24 August 2019.

READ MORE |COVER: Feisty And Fearless Pioneers Thandi Ndlovu & Nonkululeko Gobodo

She had given so much to South Africa and its people – through the apartheid years and during the 25 years of democracy, literally building a better future, first through her medical practice at Orange Farm and then through her company, Motheo Construction Group and the scholarships for tertiary education granted by her Motheo Children’s Foundation.

That sunny winter’s afternoon, I asked her if she, at the age of 65, was considering retirement, and she laughed. A lively, amiable laugh. She told me she was healthy and strong and easily worked 12 to 13 hour days.

READ MORE | WATCH | Making Of The Women’s Month Cover: Thandi Ndlovu & Nonkululeko Gobodo

She loved hiking, and has climbed Kilimanjaro twice, reached the base camps of Mount Everest and Annapurna in Nepal. At the time of the interview, she was training to climb Machu Picchu, the famed ruins in Peru’s mountains.

One of her biggest passions was to make a difference in people’s lives and to motivate people to achieve the best they could. The other was to redress the racial tensions that still remained in South Africa.

Dr Thandi Ndlovu, South Africa is poorer for your passing.

-Jill De Villiers

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