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You Only Live Twice

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Science is pumping in billions searching for solutions that will help humans live longer – and better – and one day even indefinitely.

If you are under 50 years old and reading this article, treat it as a crystal ball – and it will tell you that chances are you may live for another 100 years.

There are species of sharks, whales and turtles that live for hundreds of years. Likewise, researchers are trying to figure out how to make you live longer, if not forever.

“If we are made from the same ‘stuff’ then what’s stopping us from achieving the same,” asks John Sanei, a futurist and entrepreneur based in Johannesburg, South Africa.

For decades, scientists have been trying to do so. But before we go to the future, we must dwell on the past, and the present.

In 1770, Africans had an average life expectancy of a mere 26 years. With newer ways to cure deadly diseases such as small pox and polio, life expectancy gradually increased. Exactly two centuries later, Africans were living to almost 47 years. In 2001, the average life expectancy of Africans rose to 51 years, in 2005 to 53 years, in 2010 to 57 years and in 2015 to 60 years.

Even with such numbers, Africans are still dying sooner than most people in First World countries where life expectancy is in the 80s.

Dr Susan Coetzer spent 14 years studying to be a geriatrician, a specialty focusing on healthcare of the elderly, at the Wits University Donald Gordon Medical Centre in Johannesburg in South Africa. She says the costs and access to healthcare are the biggest barriers. In Africa, according to Coetzer, poverty and lower education levels link to both frailty and cognitive diseases lowering life expectancy.

“Other risks are because of lifestyle-related problems like diabetes, hypertension and obesity. The HIV epidemic has also decreased life expectancy in the past, but with the availability of treatment, this has improved and we will certainly see more HIV-infected older people in the future,” she says.

As the universe often works, what has an advantage also has a disadvantage. Old age often comes with various accompanying diseases that require constant supervision and medication. The more old people Africa has, the more money it needs to pay for their upkeep.

“Older patients are at a higher risk of becoming frail and frail patients have been proven to cost more – in terms of hospitalization, medication and other needs and of course, the additional care. Even most of the developed countries are battling to budget for the increased financial impact,” says Coetzer.

It is true. In October last year, South Africa had 17.5 million social grant recipients and 3.7 million of them were the aged. There are also few specialists to give proper care to the elderly.

“There are less than 20 geriatric specialists in South Africa serving a population of more than seven million people older than 60 years,” says Coetzer.

The good news is we are in an era where scientists are developing the technology to prevent aging and the diseases associated with it.

If they succeed, you could work and live long without experiencing most symptoms of old age.

For this, it will take an understanding of our genes and aging itself.

According to Dr Samantha Baron, a research and development scientist at Optiphi Skin Care in South Africa who is an expert in genetics and deoxyribonucleic acid (DNA), the primary cause of aging is damage to structures within the cells.

“Damage within the cell can be induced by oxidative stress, glycation, telomere shortening, mutations and epigenetic contributions. The progression of this damage is what leads to eventual cell death and what we know as the general cause of aging,” she says.

It means every time you celebrate your birthday, the probability of death increases. The older you get the more you become prone to diseases like Alzheimer’s, cancer, diabetes, heart disease and arthritis — all associated with age.

Dr Aubrey de Grey, a biomedical gerontologist, and co-founder of the Strategies for Engineered Negligible Senescence (SENS) Research Foundation tells FORBES AFRICA these can be avoided. Instead of solving death, he looks at extending life.

Dr Aubrey De Grey. Photo supplied.

“Aging can absolutely not be ‘cured’ but it absolutely can, although not yet, of course, be eliminated by medical interventions that are not cures…

“We already feel comfortable with spending lots of money trying to make Alzheimer’s history, so if we stop pretending that it is somehow separate from ‘aging itself’, we will have taken a huge step towards wanting to make that history too,” he says.

READ MORE: From Death Comes Life

De Grey believes we can increase our lifespan by periodic, comprehensive repair and maintenance of the human body.

“We want to restore the molecular and cellular structure and composition of the body to something like how it is in early adulthood. That means things like using stem cells to replace cells that the body does not naturally replace on its own by cell division when they die, or introducing new enzymes to break down waste products that the body does not naturally break down,” he says.

Baron agrees. She says if scientists could delay cell death by reprogramming cells, increasing cellular lifespan and increasing the efficiency in damage repair mechanisms, they could potentially prevent the onset of diseases associated with aging.

“If true cellular regeneration can be accomplished, then these diseases can be treated and the damage reversed.”

Humans are already able to manipulate the longevity of organisms.

A number of researchers in the United States (US) identified a drug that delays several age-related symptoms in mice. It has sparked massive debate and research in the world of science.

“With an experiment that replicated stem cell-like conditions, Salk Institute researchers made human skin cells in a dish look and behave young again, and mice with premature aging disease were rejuvenated with a 30% increase in lifespan. The Salk Institute expects to see this work in human trials in less than 10 years,” says Sanei.

A growing interest in this field also led to biologists at Osaka University in Japan to discover a new way to nurture and grow the tissues that make up the human eyeball. Using a small sample of adult skin, they are able to grow retinas, corneas and the eye’s lens.

Another team of researchers in the US injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.

Longevity Escape Velocity

According to Sanei, in the next 10 to 12 years, we will hit ‘longevity escape velocity’ — the point at which, for every year that you’re alive, science is able to extend your life for more than a year.

According to Oliver Medvedik, a Director at the Maurice Kanbar Center for Biomedical Research and VP of the longevity-focused non-profit Lifespan.io, interventions are being developed that “reprogram” the chemical signature of the genome, referred to as the epigenome, to a more youthful state.

“The epigenome is largely responsible for determining what the status of each of your cells is. As an adult, you typically don’t want this status to change, but as we age, it does change for the worse,” he tells FORBES AFRICA.

There is also a new class of drugs being developed known as ‘senolytics’ that specifically target and destroy cells that are too far gone and are causing secondary damage in the body. These aged cells are referred to as ‘senescent’.

“Tremendous progress has also been made in learning exactly how to reprogram the epigenome of cells so that they become new adult stem cells. These can then be reintroduced into the body to potentially promote the rejuvenation of tissues and organs, after perhaps senescent cells have been cleared,” says Medvedik.

The low-hanging fruits are small molecules that may help slow down aspects of the aging process and allow us to live healthier and longer.

“One such candidate molecule has been known for many years as a Type 2 diabetes treatment, metformin, and is now being set for clinical trials,” says Medvedik.

Scientists are also debating how long humans can possibly live in the future. Some say we will live up to 150, others say 200, and some go as far as a 1,000 years.

Baron says that at this point in time, this is mere speculation.

“It is too premature to accept a maximum lifespan of humans. Eventually, science may lead to the first 200-year-old. I would have to say that living to a 1,000 years old is highly improbable.”

Similar to De Grey and Medvedik, she says to increase lifespan, research needs to focus on improving DNA repair mechanisms, making it more efficient. This would slow down the progression of accumulated damage within the cells and consequently aging. The cells will be able to maintain homeostasis for longer.

Alternatively, she suggests the focus to be on reversing the signs of damage through cell regeneration where the healthy and younger state of the cell is obtained.

“Presently, all we can do is try to minimize the damage we provoke on to our cells by controlling our environmental factors (i.e. eat healthy, exercise, don’t smoke etc) as well as understanding our genetic predispositions. For example, at Optiphi, we offer a comprehensive DNA skin test to decipher your genetic predispositions to certain aging characteristics. Results from this test allow one to approach skin aging from a holistic point of view,” she says.

According to Baron, from an aesthetic point of view, the future market will benefit more from cell regeneration through reprogramming.

“This way you reprogram your own cells to their younger state and maintain the youthfulness of your skin. From a medical stand-point, regeneration of whole organs is definitely the future of regenerative science and exciting advances are happening in this field,” she says.

And indeed, success will mean high profits for those who invest.

Investing in the immortality industry

The rich and famous are ploughing billions into research as they try to solve the issues of ‘growing old’.

“The main wealthy people investing in this space are the techno-visionaries like Peter Thiel, Vitalik Buterin and Michael Greve but increasingly there are also people like Jim Mellon whose expertise is not in tech investing. The field is growing fast,” says De Grey.

Those with money are really keen on this next new frontier.

According to Bay Area News, Scott Smith, founder and CEO of the San Francisco-based investment bank, Viant Capital, said “the Venture Capital community has finally woken up to the fact that, next to millennials, this is the largest market in the world and it’s grossly underserved”.

The last 24 months has seen a huge uptick from the investment community.

Google’s Calico, founded in 2013, has more than $2.5 billion in funding. It paved the way for other startups and foundations like Apollo Ventures, Oisin Biotechnologies, Longevity Fund, Kizoo Technology Ventures, Methuselah Fund and Jim Mellon’s Juvenescence.

If investments trickling in are anything to go by, there is a lot of money to be made in the industry. For example, UNITY Biotechnology reported cash and investments of $198 million as of June 30 compared to $92.2 million in December.

“The increase in cash reflects net proceeds of $59.9 million from UNITY’s Series C convertible preferred stock financing, and $75.9 million from UNITY’s initial public offering. We ended this quarter in a strong financial position as a result of our recent financings. We are well-resourced to move towards our goal of extending human healthspan,” says Keith Leonard, the Chairman and CEO of UNITY in a press statement.

The company is already in first-stage human trials.

“We treated the first patient in our Phase 1 clinical trial evaluating UBX0101 in moderate to severe osteoarthritis of the knee. This is an important step in assessing the role that eliminating senescent cells may play in the treatment of diseases of aging such as osteoarthritis, and we expect to share initial results in the first quarter of next year,” says Leonard.

Big business realizes there is need for startups working in this space.

Ichor Therapeutics, a biotechnology company in New York that develops therapeutic interventions for age-associated diseases, is one of them. It has created Grapeseed.Bio, a life science strategic fund and accelerator program where life science entrepreneurs receive up to $100,000 in seed funding, technical training, full access to Ichor’s research laboratory and mentorship in exchange for equity.

“Direct funding vehicles like Grants for Growth and the TC Growth Fund, combined with mentors and a physical facility at the Tech Garden, have cultivated many promising companies in the software and tech sectors. We want to do the same in the life sciences,” says Kelsey Moody, CEO at Ichor Therapeutics and Managing Partner of Grapeseed.Bio.

The $331 billion anti-aging market

In South Africa, Mic Mann, a futurist, through his advertising and marketing agency Mann Made, co-organizes the SingularityU South Africa Summit. This year, in October, the summit is bringing to Johannesburg speakers like De Grey from all over the world to also discuss aging, longevity and a “future-proof Africa” to make sure we embrace this wave of technology coming our way.

Tickets for the whole two-day event cost between R14,850 ($1,012) and R18,150 ($1,239) and he says they are almost sold out. That’s steep prices for a country where there are more people on social grants than are employed.

“There is massive interest. We have about 100 tickets left. We are going for 1,800 people this year. Last year, we sold out at 1,300 people,” says Mann.

According to Mann, there are many investors getting into the immortality industry.

“I think there will always be a debate or drive of humanity on how we will solve the issue. Firstly, we will become amortal [pursuing a lifestyle that defies the process of aging], but we could still fall off a car or train and die. Eventually, we will become immortal and able to put our conscience in another being or hard drive,” he says.

According to the global anti-aging market research report by Orbis Research, a leading market research company, the anti-aging market is expected to reach $331.41 billion by 2021.

“The industry is exploding in size. I have seen a 1,000 percent increase in the last 18 months in investment in life extension research and technology. Everybody realizes that if life extension can fulfil its promise, many new billionaires will be made,” says Sanei.

According to Sanei, the worldwide pharmaceutical market surpassed $1.1 trillion in 2016. In 2018, the top 10 pharmaceutical companies alone are projected to generate over $355 billion in revenue.

The problem is, according to Sanei, it currently costs more than $2.5 billion, sometimes up to $12 billion, and takes over 10 years to bring a new drug to market.

John Sanei. Photo supplied.

“Nine out of 10 drugs entering phase one clinical trials will never reach patients. As the population ages, we don’t have time to rely on this slow costly production rate. Some 12 percent of the world population will be 65 or older by 2030, and diseases of aging like Alzheimer’s will pose increasingly greater challenges to society,” he says.

Although there are billions being poured into the longevity economy, many ventures have not made money.

“Very little revenue was made in the last few years…However, most life extension and longevity companies are not trying to get quick products to the market. They are searching for the holy grail of medicine: a pill or a therapy to overcome aging. This product, if successful, could generate hundreds of billions of dollars. A few billion people may end up using it eventually,” says Zoltan Istvan, a politician and former journalist who narrowly escaped death and is now trying to prove we can live longer.

While working as a journalist in Vietnam for the National Geographic channel, he almost stepped on a landmine in the jungle. It was such a nerve-racking experience he dedicated the rest of his life to overcoming death.

“It’s hard to pin down what the industry is actually worth, since so many new medicines and robotic parts are not for sale yet and are in development. But I would venture to say that some of the life extension founders and CEOs may eventually become some of the first trillionaires on the planet. If they are successful, they will be able to sell their products to virtually every person on the planet, since almost everybody wants to live longer,” Istvan tells FORBES AFRICA.

According to him, there are only a few reliable medical regenerative products on the market today.

“A few pills are coming in the one-two year pipelines that are FDA-approved and will help people live longer. But there’s an expectation that within five to seven years, an enormous amount of products will hit the market. The problem is which products are ‘snake oil’ products that aren’t FDA approved, and which are really useful for making people live longer. This will take a discerning consumer to know the difference,” he says.

Istvan loves life. His father died last year due to old age.

“Some life extensionists are afraid of death. Not me. I just love life, and since I don’t believe in an afterlife, it’s imperative I make the life I have here on earth last as long as possible — hopefully forever. Death is terrible. It’s forever. I’m haunted by it. I’m not afraid of death, but I’m haunted by my life disappearing forever — of there being no more existence of me,” he says. Istvan predicts we will gain a free year for every year we live past 2020.

“That is how fast the technology of anti-aging is developing. But at some point of this J-curve chart of life extension and living longer, humans hit a point — probably in 25 years or so — when technology and radical science simply overcome all our biological issues, and then we will live indefinitely or at least hundreds of years.”

He says hospitals may have to shut their doors.

“Medical care will go the way of the dinosaurs. At some point in the next 25 years, humans will have such good medicine and science, that pharma companies, hospitals, and doctors will begin to realize they are no longer needed. It won’t happen overnight, but by the end of this century, there will be 90% less hospitals,” he says.

It would mean life extension would have arrived. Right now, we think of medicine in terms of managing disease and how old we are. But in the future, according to Istvan, we will think in terms of getting rid of all disease and physical discomfort forever.

De Grey disagrees.

He says the only difference from the hospitals now will be that most of what hospitals will give you will be preventative.

“All it will shift is the way we think about that fictitious concept that we currently call ‘aging’ itself. We will understand that there is no such thing …,” says De Grey.

What about Africa’s existing problems?

Three generations of Black women smiling

Some argue that in Africa, however, private healthcare is expensive and government hospitals are struggling to treat people, let alone fund aging research.

De Grey, however, says there is still far too much early-life mortality in Africa, more than in the rest of the world – but as of 2015, not a single country in the whole world, including Africa, had a life-expectancy below 50.

“Therefore, Africa is catching up, which, of course, means that it is on course to have the same age-related health crisis that the industrialized world already has. Thus, it is highly timely that African nations should start to pull their weight in this space.”

READ MORE: Investment Marketplace Coming To Africa

Baron says should the lifespan of people increase, we will have bigger problems such as the ever-increasing population, further decline in food and water sources, and large economic transformations that will need to happen.

“[These] problems are already of major concern today and should be addressed before we consider further burdening our already limited resources,” she says.

Istvan sees it another way.

He says if people think they will live hundreds of years, they may not have children or even get married in the first 100 years of their lives.

“This of course will help with the overpopulation issue, and have significant structural ramification for society and human culture.”

There is another challenge. Life extension is most likely to broaden inequality. We may have a world where the super-rich can cheat death while the poor continue to die.

Zoltan Istvan. Photo supplied.

“The problem, of course, is that only the rich Africans will benefit at first. And this will be a hard fact to swallow for those people that live in poverty in Africa,” says Istvan.

De Grey however argues that such treatments will be for free.

“Keeping people healthy pays for itself so spectacularly fast that it would be economically suicidal for any country not to make the necessary investment to ensure that access is not limited by ability to pay. Today’s high-tech medicine for the elderly is not an informative precedent at all, because it doesn’t work – it doesn’t keep people healthy,” he says.

Istvan however further argues that it’s unlikely that a single pill will make people immortal. He says it’s likely to come in a combination of treatments and bionic organ replacements.

“It’s likely to take years of genetic treatments, shots or IV drugs, and organ replacement surgeries. At first, when this starts happening in 10 or 20 years, it will probably cost hundreds of thousands of US dollars, if not millions,” he says.

Longevity would mean a world where the global economy will surge, as people will be able to work much longer and stay younger much longer. Permanent retirement may be a thing of the past and people may be able to do multiple careers over hundreds of years.

 

Longevity’s impact on savings

Currently people retire at about 60 years old. If people continue to live far longer, this will be at the peak of their earning capability.

If you live into your 100s and are as strong as you were in your 30s or 40s, you will still be a part of the working population.

“Extending the human lifespan by 30 years and postponing the current retirement age would generate a massive global GDP boost,” predicts Sanei.

Currently, people retire at about 60 years old. If people continue to live far longer, this will be at the peak of their earning capability.

According to Alexander Forbes, a financial services group headquartered in Sandton, the richest square mile in Africa, retirement savings in South Africa currently amount to R4.4 trillion ($300 billion).

“[It’s] an accumulation of assets that could only have been reached because of policymakers’ insistence that if an employer does offer a retirement fund (or funds) to employees, it is mandatory for all employees to participate in the fund,” it says in its Benefits Barometer report in 2017.

This number is expected to grow as people continue to live longer. South Africa has 4.4 million people over 60 and 2.9 million over 65. According to the report, by 2050, the total population over 60 is projected to be over 6.4 million.

Sanlam, a financial services group based in South Africa, says longevity is a blessing and burden. For its centenary celebrations, the group is focusing on answering longevity questions. Through its advert, the company uses a 10-year-old ambassador to ask questions like, ‘if the person who will live to 200 has already been born, would they stay younger for longer or get older later? How long will they study for? At what age will they retire? How many jobs will they have? Will they choose the same partner for life? How many kids will they have? Will anything come with a lifetime guarantee? How would you plan for a financial future?’

“As a future thinking organization, we wanted to look into the future. We believe in long-term planning. Already, South Africans can’t retire comfortably. Only 6% South Africans retire comfortably so we had to make sure people think about the future,” says Sanlam’s marketing chief, Mariska Oosthuizen, to FORBES AFRICA.

Mikel Moyo, co-founder of Mphato & Associates, a tax consultancy firm in South Africa, says traditional financial planning speaks to retiring at age 65. Living longer means longer working lives.

“It’s is a scary thought,” says Moyo.

“Try speaking to a 30-year-old about retirement planning. The typical response is ‘65 years is 35 years away, why do I need to save now’. What people do not understand is they only have 12 pay cheques per year. This means they only have 12 opportunities to live the life they want to live, to pay for all their obligations and save for retirement. They do not have that perspective. So the rational prediction is that if people currently think 30 years after retirement is long, what happens when it’s an extra 100 years?” According to Moyo, we don’t communicate well about finances as Africans.

“We need to be able to talk about money and speak out against every bad behavior if we are to survive. If we are to live longer, we have to understand ourselves.”

Anne Cabot-Alletzhauser, Head of the Research Institute at Alexander Forbes, says longevity means the financial industry has to break away from the notion that you have to retire at a certain age.

“One of the biggest mistakes we have made in South Africa is that we would retire people at the age of 60 or 62 to make way for youth to rise up to senior positions much faster. But in fact, research shows you that you will get better productivity by having people with more experience…You can get transformation without retiring people with experience,” she says.

According to the Alexander Forbes report, there has been a rise in the number of elderly who are bread winners. Between 1996 and 2011, this number increased from 1.7 million to about 2.9 million households.

“Elderly people also appear to be continuing to work later in life. This could be because of economic pressure to continue generating an income, or it may be a reflection of a global trend: educated individuals are beginning to see that they still have value to offer professionally, even if they have hit some arbitrary cut-off date.”

She adds that people make assumptions that as you get older, you become an economic burden to the country.

“We need to change our attitude towards healthcare because the healthcare you give to someone past the age of 60 is completely different to the one you give to someone younger…If you get it right, you significantly reduce the cost of healthcare which is one of the biggest fears of what is going to happen if longevity increases.”

She says the biggest challenge for financial planning is post retirement because you have no idea of what is going to happen to your health.

According to her, quality-care of the elderly exists in the communities, not retirement homes.

“We have had a nice situation whereby adults take care of their children and the children grow up and take care of the elderly,” she says.

The problem is, according to Cabot-Alletzhauser, the financial services industry uses first-world solutions to try solving third-world problems.

“I have a real problem with the financial services industry. It is touted to be first-world quality, and indeed it is, but it solves first-world problems…The insights it has applies maybe to the top 5% of the population.”

She says retirement savings is not a priority for South Africans.

“Most South Africans work, take their income home and take care of their siblings and even grandparents. That’s our modern reality…We don’t have a stable middle class in South Africa. People enter the middle class by virtue of what their income is but they don’t stay there because they immediately get into credit problems…We aren’t focusing on how we create stability during the journey and jumped to retirement,” she says.

Instead of saving for retirement, Cabot-Alletzhauser, says she would support investing in property.

“If they have a house, when they retire, they can rent some of the rooms and make an income…There is a mistaken notion that you are going to retire at 60 and then live to 120. People will keep working if they are to live to 120. I am 69 and I am still capable of working and will continue working.”

 

Preserving and reviving dead people?

Finland-based entrepreneur Filip Poutintsev first heard about the concept of aging when he was three years old.

“I was playing with my grandfather and suddenly asked him ‘why are you so old?’. His reply was very straight forward: ‘we all get old’. After hearing that, I started crying hysterically, as at that point I realized for the first time that I too will get old,” he tells FORBES AFRICA.

At about age 12, his teacher told him about cryonics – deep-freezing the bodies of people who have just died, in the hope that scientific advances may allow them to be revived in the future.

“For me, that was like a light at the end of the tunnel. There was finally hope that I may not have to die.”

His curiosity about life and aging grew. He decided he wanted to be frozen after death but was appalled by the limited research in the industry. It compelled him to actively engage.

“I remember reading a few years ago an article about immortality that stated that if we spent as much money on life extension research as we spend on whitening our teeth, we would already be immortal. This was kind of a wakeup call for me. I realized deep inside that if I do nothing and just wait I might not make it to the time biological immortality is possible,” he says.

He founded the Immortality Foundation, which tries to create visibility and attention for anti-aging, longevity and life extension research.

“You see aging is a physical process, and the aging of humans is not different than the aging of a car, it’s just more difficult to fix.”

Breakthrough doesn’t mean everyone with access will live long. Poutintsev says once we eliminate death caused by aging and age-related diseases such as cancer, the biggest cause of death will be accidents, as our bodies will still be vulnerable to physical damage.

“If you want to live to 1,000 years, you need to be very careful not to die in traffic accidents for example. Actually, if we look at modern day statistics on death, we can calculate that even if we will become biologically immortal, our chance to live for 1,000 years is only 60%, due to all sorts of accidents,” he says.

The study of cryonics is growing rapidly.

“The process of cryopreservation involves cooling a legally-dead person to liquid nitrogen temperature where all physical decay essentially stops – with the goal of preserving tissues, organs and especially the brain with its associated memories and personality as perfectly as possible,” says the Cryonics Institute on its website.

A person held in this state is called a cryopreserved patient.

“We do not consider the legal definition of ‘death’ as a permanently irreversible state. We believe that the incredible advances being made today in biology, medicine, computers, nanotechnology and much more, inevitably point to a future where advanced science will be able to revive these patients and restore them to health and even renewed youth.”

There are more than hundreds of cryopreserved patients across the world, says the institute. And it’s costly.

A minimum whole-body suspension costs $28,000 at the Cryonics Institute. Other companies charge more.

For example, the same procedure reportedly costs $200,000 at Alcor4, $155,000 at the American Cryonics Society, $36,000 at KrioRus and $150,000 at Trans Time.

Just as vaccines, surgeries, sterilization and antibiotics ushered in a new age of longevity, new technologies like robotics will expand it further.

“Humans are slowly becoming cyborgs with artificial hips, dentures, and soon will replace all their organs with better performing bionic ones. So it’s quite possible that overpopulation won’t really affect the world, as humans will be machines, and can do things like interplanetary travel as well as only use sunlight to run their bodies, and not food or water or oxygen,” says the futurist Istvan.

There is also an impact for the geriatrics industry.

“I hope that in geriatrics, we will still maintain the ‘human’ part of interacting with patients, instead of everyone just ‘plugging in’ like a robot, says Coetzer.

Sanei agrees. He says most people he speaks to say they never want to become a cyborg but we will naturally become robot-like.

“Let’s go back to the beginning when humans developed the earliest technologies – fire and stone tools. These tools gave people new capabilities, and became extensions of our physical bodies. As we move into the future, we are not even going to notice becoming part-machine, because it’s going to be a sensible thing to do at each point in the journey,” says Sanei.

Entrepreneurship opportunities

Tech billionaires like Google co-founder Sergey Brin are already working on combating aging in the longevity labs of the west. African entrepreneurs have begun to see the merit of such research. One of them is 41-year-old Dr Danny Meyersfeld.

“I love research and being in the lab but there comes a point where you need a clean break from academia otherwise you will be there for the rest of your life,” he says.

We meet him at his offices in Illovo in Sandton. He has invited us to see the DNA-testing in his lab. Meyersfeld is the founder of DNAlysis Biotechnology.

Here, his team conducts different tests – for weight management, disease management, sports performance, skin health, skin-aging and cognitive health.

Dressed in blue jeans and a white shirt, he tells us how he started the business in 2008.

“I had a PhD in Molecular Biology and I didn’t know what to do with it…At the time, we wanted to bring biotech advancement to the South African healthcare environment and to bridge the knowledge gap that exists between academia and the consumer. There is a wealth of knowledge and research that sits in publications and academia that never gets to the people. If research is not done to make a difference to the average human, then what’s the point,” says Meyersfeld.

His idea wasn’t easy to sell.

Danny Meyersfeld. Photo by Motlabana Monnakgotla.

“For the South African market, I think we were about five years too early for these types of tests. We were this lone voice trying to sell a product but also trying to educate and create a market for something that hadn’t existed before,” he says.

The advantage was having examples from the US and European market.  They were able to learn from the mistakes of those companies to find the right model.

“But the challenge was still a lack of awareness of these types of technologies especially with healthcare practitioners because that’s where our market was. We didn’t want to go straight to the consumer; we wanted to work with dieticians and doctors so genetics can be a daily part of their work.”

According to Meyersfeld, longevity is possible but it’s more about being healthy and understanding your DNA.

“I would rather live to 90 and maintain my health than live to 120 and suffer for the last 20 years,” he says.

 

Anti-aging in the beauty business

Dr Reza Mia is the Chief Operating Officer at Anti-Aging Art, a medical aesthetic and wellness center focusing on minimally invasive anti-aging and cosmetic treatments.

“People kept coming to me and saying, ‘aren’t you a doctor, don’t you do botox, don’t you do fillers and I went and did the courses to satisfy that need. Slowly, they kept coming and bringing their brothers, sisters, friends until it became a full-time job,” says Mia.

According to Mia, the industry is growing.

“In South Africa, because it started a bit late, it’s growing faster than the rest of the world. We are normally fully-booked but we try to add doctors to take care of that demand.”

The company says it serves 500 to 600 clients every month. They are 60% women and 40% men, ranging from teenagers to people over 80. Patients pay R3,000 ($205) on average per visit.

“Mostly, people want to fix tiny problems like frown lines and sagging faces. A lot of the time, it’s small things that make them self-conscious, like sweating too much on the face and underarms. Sometimes, they just want maintenance work all over the body,” says Mia.

She says one of the challenges is a lack of the right regulations.

“We see a lot of practices opening up not owned by doctors and they obviously don’t know about the ethics…It’s hurting the industry because people are seeing other people looking unnatural and they think that’s what fillers do.”

Mia wants to expand the business, through franchising, to Tanzania and Dubai in the near future.

The quest for immortality may be very much in the future, but these futurists, doctors and scientists believe that with technology, we are irresistibly closer to finding a cure for aging than we have ever been before.

Never say die.

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Cover Story

Pioneer For Women In Construction Thandi Ndlovu has died

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The cover of the August (Women’s Month) edition of Forbes Africa beautifully captures the essence of the woman I interviewed only a few weeks ago. Gracious, soft-spoken, brimming with life and energy. Dr Thandi Ndlovu impressed the entire Forbes crew on that afternoon cover shoot with her broad smile, and open yet powerful demeanor.

It is with great sadness that Forbes Africa heard of the accident that took her life on Saturday the 24 August 2019.

READ MORE |COVER: Feisty And Fearless Pioneers Thandi Ndlovu & Nonkululeko Gobodo

She had given so much to South Africa and its people – through the apartheid years and during the 25 years of democracy, literally building a better future, first through her medical practice at Orange Farm and then through her company, Motheo Construction Group and the scholarships for tertiary education granted by her Motheo Children’s Foundation.

That sunny winter’s afternoon, I asked her if she, at the age of 65, was considering retirement, and she laughed. A lively, amiable laugh. She told me she was healthy and strong and easily worked 12 to 13 hour days.

READ MORE | WATCH | Making Of The Women’s Month Cover: Thandi Ndlovu & Nonkululeko Gobodo

She loved hiking, and has climbed Kilimanjaro twice, reached the base camps of Mount Everest and Annapurna in Nepal. At the time of the interview, she was training to climb Machu Picchu, the famed ruins in Peru’s mountains.

One of her biggest passions was to make a difference in people’s lives and to motivate people to achieve the best they could. The other was to redress the racial tensions that still remained in South Africa.

Dr Thandi Ndlovu, South Africa is poorer for your passing.

-Jill De Villiers

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Cover Story

Feisty And Fearless Pioneers Thandi Ndlovu & Nonkululeko Gobodo

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Thandi Ndlovu and Nonkululeko Gobodo, moulded by South Africa’s apartheid past, tore their way into male-dominated sectors , leading them boldly through a quarter century of democracy. Failure was never an option.


On a sunny winter’s afternoon in a quiet suburb of Randburg in greater Johannesburg, a second white Mercedes-Benz pulls up in the driveway of a photographic studio, and finds a shady spot to park.

Already seated next to a pool glinting blue in the sunlight, an elegant woman dressed in black and white sips green tea and talks about her early life growing up in the former Bantustan of Transkei in South Africa.

Absorbed in recounting her story, she looks up as a tall, slender woman, also in a chic black and white ensemble, walks towards her. The two women beam in recognition. They are here to be photographed by FORBES AFRICA and to share their unique stories as businesswomen in two traditionally white male-dominated sectors – auditing and construction.  

This year, South Africa celebrates 25 years of democracy. As the country started shaking off the shackles of oppression in the 1990s, both these women embarked on their paths to greatness. Both had been moulded by the harsh final years of apartheid, gaining the strength and conviction to fight for what they believed in.

In the process, they built successful businesses, changed perceptions and became role models.

And as with all stories of achievement, their journeys came with times of adversity.

Nonkululeko Gobodo. Picture: Motlabana Monnakgotla

Nonkululeko Gobodo: The visionary in auditing

 As a young girl, Nonkululeko Gobodo had very low self-esteem. She was shy and quiet and as the middle child in a family of five children, she felt overshadowed by her very outgoing older siblings. Her mother made it clear that she thought Gobodo wasn’t “going to amount to anything”.

Yet, there were factors in her upbringing, at home and in her community, which shaped her and prepared her for a future as a captain of industry.

Her mother was very hard on her. “I’m someone who needs affirmation and she did the opposite of what I needed. Fortunately, my father was doing that, he was doing the affirmative things.”

As an educator, her father was excited when she achieved “goodish” results at school, even slaughtering a sheep in celebration.

“When my parents were running shops, I used to be the one who would help in running the shops during the holidays. And I was quite young to be given the responsibility. My mother was literally taking a holiday, and I would run the shop perfectly, no shortage or anything like that. So, in spite of the fact that she was too hard on me, she must have thought she was nurturing this talent and making me strong.”  

Growing up in the then independent Transkei (now the Eastern Cape province of South Africa), Gobodo was largely sheltered from the impact of apartheid in other parts of the country.

“I lived in this world where you were sort of cushioned from what was happening in South Africa. So you were socialized to be a fighter, to be strong. My parents used to say that we should never allow anybody to tell us there were things we cannot do,” she elucidates.

It was an everyday thing to see black people running a variety of formal businesses like hotels, garages and wholesalers.

“I suppose I was very fortunate in that I was raised by these parents who were in business, who were working very hard during those times and with very strong personalities, both of them. Within the Xhosa tribe itself, although there is patriarchy and all that, Xhosa women are very strong and they are sort of equal partners with their husbands.”

Still very young, Gobodo fell pregnant. Her parents insisted on marriage. The marriage would end several years later, after the birth of three children, when she was 34 years old.

While taking a gap year working at her father’s panel-beating shop in Mthatha (then Umtata), during her first pregnancy, Gobodo discovered her calling. While her parents thought she would be well-suited to a career in medicine, she found joy in accountancy.

The gap year also revealed her innate strength to stand up for what she believed in. For the first time, she encountered racism. White managers remained in place when her father bought the business from the Transkei Development Corporation (TDC).

“They were really so upset by these black people who had taken over this business, and they were just bullying everyone. So I was able to stand up to them and then I realized I’m actually smart, I’m actually not this thing that my mother was saying, that I’m not just smart, but I’m strong, I’m tough, I can stand up to these men during apartheid years and it was not because my father owned the shop, but it was this thing of suddenly discovering who you are for the first time and just waking up to who you are and suddenly knowing what you wanted to do. Oh wow, accountancy, I didn’t know about that,” she smiles.

She was also inspired by the fact that black auditors did the books for her father’s business. They were WL Nkuhlu & Co, owned by Professor Wiseman Nkuhlu. Her father supported her decision to study BCom and she enrolled at the University of Transkei (now Walter Sisulu University).

Gobodo became a star performer at university and her confidence grew. After qualifying, the university offered her a junior lectureship. While there was no racism in the academic environment, it was here that she had her first taste of gender discrimination. A male colleague instructed her to do filing. She thought this was ridiculous considering her position, and she refused. He treated her as an equal from then on. 

“I made a decision to fight the system differently,” she says. “I was sure there was no system that would determine who I am and how far I can go. I used to say this mantra to myself: ‘Your opinions of me do not define me. You don’t even know who I am’. So I never allowed those things to get to me.”

Early on, she already had a vision to have her own practice, so she was not distracted by her peers complaining while doing their articles. She was determined to take advantage of the opportunity to get the best training she could get. “Those guys never became chartered accountants, so it was a wise thing not to join them,” she smiles.

In 1987, she made history when she became South Africa’s first black female chartered accountant.

Working at KPMG, she grew to rapidly build her own portfolio of challenging assignments.

“It was my driving force right through life to prove to myself and others that there was nothing I couldn’t do. And for me, being black really gave me purpose. I can imagine that if I was living in a world that was readymade for me, life would have been very boring,” she says.

She was offered a partnership eight months after her articles. She would be the first black partner, and the first woman. It was very tempting. But she remembered her vision to start her own practice and taking the partnership would be “the easy way out”. 

So she moved on to the TDC, where at the age of 29, she was promoted from internal audit manager to Chief Financial Officer within three months. Again in 1992, she decided to break “the golden chains” of the TDC to pursue her destiny. But first, she restructured her department and empowered five managers; thoroughly enjoying the work of developing leaders, and setting the tone for the business she runs now – Nkululeko Leadership Consulting.

READ MORE : WATCH | The Making Of The New Wealth Creators Cover

 At the time, her father questioned her decision to leave such a lucrative position to take the risk of starting a business. “Everybody was so scared for me and was discouraging me. I realized these people were expressing their own fears. I have no such fears. And it’s not saying I’m not fearful of the step I am taking, but I’m going into this business to succeed.”

The best way to do that was to step into the void without a safety net. So, no part-time lecturing job to distract her from her vision. “If I had listened to them, how would I have known that I could take my business this far?”

She describes herself as a natural entrepreneur. Yet, the responsibility of leading a business is not a joke.

“It sobers you up,” she says. “You realize you have to make this work, otherwise you’re going to fail a whole lot of people. But when you have the courage to pursue your dream, things sort of work out. Things fall into place.”

Eighteen months into the practice, she took on a partner and felt an “agitation for growth”. It came with a “massive job” from the Transkei Auditor General, and things changed overnight. With only four people in their office, they now needed 30 to complete the assignment and they hired second and third year students who attended night lectures at the university.

“At that time, as a black and a woman, you had to define your own image of yourself, and have the right attitude to fight for your place in the sun. And I can’t take for granted the way I was socialized and raised by my parents. My father was such a fighter. And he shared all his stories at the dinner table. He used to say in Xhosa: ‘who can stand in front of a bus?’, so you just have those pictures of yourself as a bus. Who can stand in front of me and my ambitions in life,” she laughs.

This self-confidence, belief in herself, direction, purpose and her clear vision steered her ever further.

“Unfortunately, I had a fallout with my partner Sindi Zilwa [co-founder of Nkonki Inc, a registered firm of auditors, consultants and advisors], and that was a hard one, a very difficult one. I used to say it was more difficult than my divorce, because that happened almost at the same time. First, the divorce started and a few months later, I divorced with my partner,” she says.

“It was a lonely time. It is amazing that out of hardship, we find an opportunity to grow and move to the next level.”

She went on a five -week program with Merrill Lynch in New York in 1994. On her return, she saw herself being cut out of negotiations to establish a medium-sized black accounting firm. While these plans were scuppered now, her vision still survived and no one could take that away from her.

She approached young professionals who were managers at the big accounting firms in Johannesburg to join her. “But you can imagine, they were young, they were fearful. It took about eight months to persuade and convince them.” 

Gobodo understood their fears as she herself had to overcome her doubts about moving from a small community in the Transkei to the big city. But the visit to New York had helped her overcome her fear. If she could make it there, she could make it anywhere.

Gobodo Incorporated was established in 1996. It was the third medium-sized black accounting firm.

The others were Nkonki Sizwe Ntsaluba and KMMT Brey.

She believes that providence has always sent “angels” to her at the right time in her life. Peter Moyo, a partner at Ernst & Young at the time, gave his time and invaluable experience leading to the establishment of Gobodo Incorporated. Chris Stephens, who was the former head of consulting for KPMG, facilitated bringing a fully-fledged forensics unit to the firm. They took up a whole floor at their new Parktown, Johannesburg offices instead of the planned half-floor.

From a small practice in Mthatha, Gobodo Inc. grew to a medium-sized company with 10 partners, 200 staff and three offices – in Durban, Cape Town and Johannesburg. It was an exciting time.

Gobodo firmly believes that visions are not static. Once a summit is conquered, there will always be another one waiting for you.

The next summit beckoned her 15 years later. Black Economic Empowerment (BEE), a program launched by the South African government to redress the inequalities of apartheid, was firmly established and accounting firms were compliant, and Gobodo Inc. started losing out on opportunities as previous joint-audits done in partnership with the big accounting firms fell away.

She started talks with Victor Sekese of Sizwe Ntsaluba to merge the two medium-sized firms.

Again, people questioned the wisdom of the move. What if the market was not ready for a large black accounting firm?

There was somewhat of a culture clash when the “somewhat older, disciplined, bottom-line” Gobodo Inc. and the “younger, more creative” Sizwe Ntsaluba teams came together.  A new culture combining the best of both emerged. Ironically, while no people were lost during the merger, some were uncomfortable with the culture change and left. 

In the beginning, “a lot of sacrifices had to be made to make this thing work. Like the name. My partners were saying Nonkululeko’s name should be in front because she’s the only remaining founder,” explains Gobodo.

Sizwe Ntsaluba wanted their name up front, and it was a deal-breaker. She decided the vision was bigger than her and she wouldn’t allow anything to jeopardize it. The company name was agreed on: SizweNtsalubaGobodo. The business grew to 55 partners and over 1,000 staff. 

“I think we underestimated how hard it would be,” she says. “Mergers are difficult in themselves, around 70% of mergers fail. People were laughing at us saying ‘ah, black people, they’re going to fight amongst each other and fail’, so we were determined not to fail. Failure was not an option.”

When they did their first sole tender, “you could smell the fear in the passages. There was so much fear”. Then the call came from the chair of the audit committee of Transnet to say the board had decided to appoint SizweNtsalubaGobodo as the sole auditors.

Gobodo had led the way to the establishment of the fifth largest accounting firm in South Africa. Her vision had been realized.

“It was just so fulfilling, really so fulfilling,” says the grandmother-of-three. “So it was time to move this thing forward.”

 She was the Executive Chairperson and Sekese was the CEO. She commissioned partners to find the best governance structure for the firm. Their recommendation was for one leader to lead the firm forward, and a non-executive chair.

“That was going to be boring for me. If I was not going to be part of driving this vision forward, it was time for me to leave,” Gobodo says. “There comes a time that the founders must leave and hand over to the next generation.”

Although she had achieved her dream, it was not easy to let go. The separation took three months.

“I learned a lot about letting go at that time. We have to let go layer by layer. I had to accept that they would do what they had to with the legacy. And here they are now, having merged with Grant Thornton. The dream was to be a true international firm, and now with SNG Grant Thornton, it is still basically a black firm going into the continent. The dream does not die. This is still a black firm taking over an international brand.”

Gobodo now heads Nkululeko Leadership Consulting, a boutique, black-owned and managed leadership consulting firm. Here, she can live her passion for developing leaders. She also sits on the boards of PPC and Clicks. The future awaits her with more promise.

READ MORE : Businesses Of The Future: 20 New Wealth Creators On The African Continent

Side bar: ‘The World Is Not Kind To Strong Women Leaders’

What were the greatest challenges she faced during her career?

“Making a success of your life in the South Africa of the past. As a black person, you always started from a place of being dismissed, as a woman, you always started from a place of being dismissed. So you had to be true to yourself and find yourself for you to be able to succeed. And that was hard. I don’t want to make it as if it was easy.

“The second thing was being a strong woman leader. The world is not kind to strong women leaders. And for me, being a strong woman leader was the hardest thing because both men and women don’t accept a strong woman leader. So you have this big vision, you are driven, you have to move things forward and if you’re a strong man, you’re accepted.

“But if you’re a strong woman, you are not. So you had to grow up and mature and try to find that balance of still moving people forward to achieve your vision, because I realized early that I would not get to the finish line without them. I could not leave them behind. So I always had to find that balance and sometimes, I didn’t do it well.

“Because there was this urgency of moving forward and you have to drag people with you. And they didn’t take kindly to that. Do I regret it? No, not really. I don’t think I would have achieved what I had. I had been given these gifts as a strong woman for a reason. I just feel sorry for strong women leaders, because it is still not easy for them today.”

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30 under 30

Forbes Africa #30Under30 list: Business, Technology, Creatives and Sport

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THE FORBES AFRICA 30 UNDER 30 LIST IS THE most-anticipated list of game-changers on the continent and this year, we bring you 120 of Africa’s brightest achievers under the age of 30 and for the first time, four categories featuring 30 in each: Business, Technology, Creatives and Sport.

From elevator manufacturing, solar energy design, to under-30s conquering the Alps and selling out the Apollo Theatre,  this year’s list demonstrates how enterprising and extraordinary the African youth is.

This list celebrates these pioneers who are building brands, creating jobs, and innovating, leading, transforming and contributing to new industries, in turn, changing the continent. 

“The future belongs to Africa and the future belongs to its youth,” says Jason Pau, Chief of Staff for International to billionaire Jack Ma, co-founder of Alibaba. He says the journey for young entrepreneurs, especially in Africa, is not always easy. Many startups fall by the wayside due to a lack of resources. In South Africa, it is estimated that the small enterprise failure rate is at almost 80% within the first three years.

Chances at success are very slim, yet Africans continue to see opportunity where many do not. The select few celebrated in this list represent those individuals who continue to persevere against the odds. It also serves as a reminder that it is possible.

“People don’t really give enough time or spend enough time in providing the right environment for entrepreneurs to grow,” Pau tells FORBES AFRICA.

So if entrepreneurship is the answer, ensuring that an environment is conducive for business sustainability is imperative.

Together with our audit partner for this list, SNG Grant Thornton, the senior editorial team worked night and day scrutinizing each candidate. For entrepreneurs, we delved into how profitable their businesses were and if they showed signs of potential growth and sustainability.

However, not only does the list look at the financial impact of each candidate, but also their reputation, resilience and ability to be role models to other young Africans.

For FORBES AFRICA, this meant endless background checks, fact-checks, emails, phone calls and research, sifting through over 1,000 nominations that poured in over the last few months. Lastly, the one factor that also played a role in the determination of the candidates was their online presence. Followers are a valuable new currency, and today’s achievers have found a way to leverage off them. This year, when FORBES named Kylie Jenner the world’s youngest self-made billionaire, it observed that her business was built mainly because of her social media and fan following. Many on our list have also been able to build on this in their own way. The creatives and sport stars lead in this regard.

This year, Sport is the newest category, opening up the list to the game-changers who are also Africa’s next generation of leaders. They have won awards, broken records, made social investments and pushed the boundaries by challenging the status quo on policies in sports. However, some of the challenges they still face include lack of resources, a gender pay gap, and an immense pool of untapped talent not yet given a chance to be in the limelight.

But no matter where they are from, these 120 list-makers share one common goal, and that is to build a better Africa.

Being an under-30 myself, I am proud to have curated the FORBES AFRICA 30 Under 30 class of 2019. At the time of going to press, all facts on the following pages were verified to be correct.

The list is in no particular order:


This year marks the fifth milestone annual FORBES AFRICA 30 under 30 list, and we have introduced a new category of game-changers. Together, they are 120 in total across four sectors: business, technology, creatives and sport. Meet the class of 2019, a stellar collection of entrepreneurs and innovators rewriting rules and taking bold new risks to take Africa to the future.

#30Under30: Business Category 2019
#30Under30: Creatives Category 2019
#30Under30: Technology Category 2019
#30Under30: Sport Category 2019
  • Words: Karen Mwendera    
  • Edited by: Unathi Shologu
  •  Assistant: Garreth Mtuwa  
  • Creative direction by: Lucy Nkosi  
  • Lead photography by: Motlabana Monnakgotla
  • Co-photography by: Gypseenia Lion   

Judges of the 30 Under 30 class of 2019

The category experts whose role it was to survey all finalists of the 2019 30 Under 30 list, rank them and provide commentary on each candidate:

  • Business: Anthea Gardner, Founder and Managing Partner at Cartesian Capital
  • Technology: Professor Tshilidzi Marwala, Vice-Chancellor and Principal at University of Johannesburg; he also deputises President Cyril Ramaphosa on the South African Presidential Commission on the Fourth Industrial Revolution.
  • Creatives: Yasmin Furmie, creative and business partner of fashion brand SiSi The Collection, South Africa
  • Sport: Nick Said, the Africa sports correspondent for Thomson Reuters
  • Audit partner: SNG Grant Thornton

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